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. Author manuscript; available in PMC: 2023 Jan 1.

Published in final edited form as: J Periodontal Res. 2021 Nov 8;57(1):173–185. doi: 10.1111/jre.12951

Figure 4. — The effect of imipramine on leukocyte infiltration induced by LPS and/or metabolic syndrome (MetS). In addition to TRAP staining as described above, the tissue sections were also stained with hematoxylin and eosin (H/E), and histological evaluation of leukocyte infiltration was performed. Representative tissue sections with H/E staining in periodontal ligament tissue or subepithelial gingival tissue are shown (A). Scale bar = 100 μm. Inset: Images were enlarged (scale bar=300 μm). The arrows indicate infiltrated leukocytes. The inflammatory scores were determined according to the degree of leukocyte infiltration and bone resorption as described in Materials and Methods (B). The data are mean ± SD (n=7–10). *p<0.01 vs **, *p<0.01 vs +, *p<0.01 vs #, *p<0.01 vs^, +p<0.01 vs ^, #p<0.01 vs ^. ^p<0.01 vs ^^. T: tooth; B: alveolar bone.

Figure 4. — The effect of imipramine on leukocyte infiltration induced by LPS and/or metabolic syndrome (MetS). In addition to TRAP staining as described above, the tissue sections were also stained with hematoxylin and eosin (H/E), and histological evaluation of leukocyte infiltration was performed. Representative tissue sections with H/E staining in periodontal ligament tissue or subepithelial gingival tissue are shown (A). Scale bar = 100 μm. Inset: Images were enlarged (scale bar=300 μm). The arrows indicate infiltrated leukocytes. The inflammatory scores were determined according to the degree of leukocyte infiltration and bone resorption as described in Materials and Methods (B). The data are mean ± SD (n=7–10). *p<0.01 vs **, *p<0.01 vs +, *p<0.01 vs #, *p<0.01 vs^, +p<0.01 vs ^, #p<0.01 vs ^. ^p<0.01 vs ^^. T: tooth; B: alveolar bone.