Skip to main content
. Author manuscript; available in PMC: 2023 Jan 18.
Published in final edited form as: Circulation. 2021 Dec 16;145(3):206–218. doi: 10.1161/CIRCULATIONAHA.121.054285

Fig. 1.

Fig. 1.

Schematic overview of the study. Substantial ASCVD risk remains in subjects of optimal/near-optimal lipid status. In the present study, our AtheroSpectrum revealed the pathogenic foaming program of atherogenic macrophages. By cross-referencing these genes with genes from peripheral monocytes from MESA participants using our novel algorithm, we identified an ASCVD 30-risk gene-set. By combining this 30 gene-panel with other factors, we created a Cardiovascular Risk score (CR-30) that depicted ASCVD risk.