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. Author manuscript; available in PMC: 2022 Jan 19.
Published in final edited form as: J Mol Cell Cardiol. 2021 Sep 3;162:32–42. doi: 10.1016/j.yjmcc.2021.08.013

Fig. 2.

Fig. 2.

Effect of phosphofructokinase activity on the relative abundances of ancillary biosynthetic pathway metabolites. (A) Schematic of study design and transgenic mouse model. (B) Consumption of 13C6-glucose-containing liquid diet over the course of 18 h. (C) Circulating glucose levels after 18 h of liquid diet feeding. (D) Circulating lactate levels after 18 h of liquid diet feeding. (E–J) Crossover plots: Influence of cardiac phosphofructokinase activity on average relative abundances of metabolites in glycolysis, glycogen synthesis, the hexosamine biosynthetic pathway (HBP), the pentose phosphate pathway (PPP), and the pyrimidine and purine biosynthetic pathways. n = 4–5 hearts/group. *p < 0.05, **p < 0.01, ****p < 0.0001, one-way ANOVA with Tukey post-hoc test. Absolute abundances of each metabolite were used for statistical analysis.