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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Brain Behav Immun. 2021 Nov 19;100:10–24. doi: 10.1016/j.bbi.2021.11.007

Fig. 8.

Fig. 8.

TLR7 deficiency has no impact on neurological dysfunction induced by polymicrobial sepsis. Behavioral function at baseline were tested 2 weeks prior to CLP procedure and tested again 4 weeks after in WT and TLR7−/− mice. (A) Motor function was evaluated by Open Field, Rotarod, and CatWalk tests. n = 12–23/group, **p = 0.0063, F(1,57) = 13.25, two-way ANOVA with post hoc Bonferroni test. (B) Hippocampus-dependent spatial working memory was evaluated by Y-maze. n = 12–23/group. ****p < 0.0001, two-way ANOVA with post hoc Bonferroni test. (C) Non-spatial retention memory was tested by Novel Objective Recognition. n = 12–23/group. Two-way ANOVA. (D-E) The forced swim test and tail suspension test. n = 12–23/group. two-way ANOVA. (F) Social Interaction Test. n = 12–23/group. Two-way ANOVA with post hoc Bonferroni test.