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. 2022 Jan 5;12:801493. doi: 10.3389/fphar.2021.801493

FIGURE 6.

FIGURE 6

Targeting TIGIT inhibits the metastasis of bladder cancer through suppressing IL-32. (A,B) Targeting TIGIT suppresses the expression of IL-32. Immunohistochemistry images showing the expression of IL-32 in bladder tissues collected from different groups of animals. Scale bar = 1 mm (A). The levels of expression of IL-32 are shown as the mean ± SD. ****p < 0.0001; t-test (B). Data are representative of four independent experiments (n = 7). (C−E) Targeting TIGIT inhibits the metastasis of bladder cancer. Metastatic nodules in lungs of mice inoculated with bladder cancer cell lines (C). The number of metastatic nodules is shown as the mean ± SD. *p < 0.05; t-test (D). Images showing HE-stained bladder tissues collected from different groups of animals. Scale bar = 100 μm (E). Data are representative of four independent experiments (n = 7).