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. 2022 Jan 5;12:785275. doi: 10.3389/fimmu.2021.785275

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Copyright © 2022 Kuley, Stultz, Duvvuri, Wang, Fritzler, Hesselstrand, Nelson and Lood

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of fMet in SSc patients associate with neutrophil activation markers. Levels of fMet, calprotectin, and NETs (myeloperoxidase-DNA complexes) were analyzed by ELISA. Shown are the correlation analyses between (A) calprotectin (Δ) and (B) NETs (∇) with fMet levels in SSc patients from Cohort I. (C) Calprotectin (Δ) and (D) NETs (∇) correlation with fMet levels is shown in SSc patients from Cohort II. Each symbol represents a single subject. Statistics were determined by Spearman’s correlation test.