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. 2022 Jan 5;12:803896. doi: 10.3389/fmicb.2021.803896

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Copyright © 2022 Zhang, Perez-Garcia, Dierkes, Applegate, Schumacher, Chibani, Sternagel, Preuss, Weigert, Schmeisser, Danso, Pleiss, Almeida, Höcker, Hallam, Schmitz, Smits, Chow and Streit.

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Phylogenetic tree and pairwise comparison of known PETases and bacteroidetal PET-hydrolyzing enzymes. (A) The tree was constructed using the RAxML-NG autoMRE algorithm (Kozlov et al., 2019) with the treesapp create command implemented in TreeSAPP (Morgan-Lang et al., 2020) with maximum bootstraps set at 1,000. GenBank entries of the putative and verified PET-active enzymes affiliated with the Bacteroidetes phylum are listed in Table 1; the entries of all other PETases included in the tree are indicated in Supplementary Table 3. The term “uncultured bacterium” refers to a not further specified microorganism derived from a metagenome or a mixed microbial consortium. (B) Heatmap representation of pairwise similarities between all enzymes affiliated with the Bacteroidetes phylum in comparison with four known PETases (IsPETase, LCC, PE-H, and PET2). The pairwise comparison was performed in MEGAX with the p-distance model. High values indicating low similarity are colored in red, low values indicating high similarity are colored in green.