Fig. 1. Timeline and milestone of colchicine in medicinal history.

The use of colchicine dates back to Ebers papyrus. Until 1833, the legendary drug was named as “Colchicine”. From 1971 to 1979, many preclinical studies demonstrated the efficacy of colchicine in the treatment of inflammatory diseases. At the end of the 20th century, mounting evidences proved that colchicine is beneficial to cardiovascular diseases, such as atherosclerosis, pericarditis, atrial fibrillation. Until 2005, the structure of colchicine was first reported, and then clinical trials involving colchicine for cardiovascular disease were actively pursued.