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. 2022 Jan 19;43(9):2173–2190. doi: 10.1038/s41401-021-00835-w

Fig. 3. The mechanisms of action of colchicine in cardiovascular disease protection.

Fig. 3

This figure shows the pathogenesis of atherosclerosis and multiple cells interaction in this progress. Colchicine inhibits: (1) endothelial dysfunction; (2) the release of proinflammatory cytokines; (3) macrophage migration, chemotaxis, and adhesion; (4) platelets and immune cells activation.