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. 2022 Jan 19;43(9):2173–2190. doi: 10.1038/s41401-021-00835-w

Fig. 4. Molecular targets of colchicine in cardiovascular protection.

Fig. 4

a Mechanism of colchicine blocking β-tubulin and then disrupting the assembly of microtubules; b mechanism of colchicine targeting NF-κB and then inhibiting many important processes in atherosclerosis; c mechanism of colchicine inhibiting NLRP3 inflammasome activation.