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. 2022 Jan 5;14:811171. doi: 10.3389/fnmol.2021.811171

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Copyright © 2022 Bakaeva, Lizunova, Tarzhanov, Boyarkin, Petrichuk, Pinelis, Fisenko, Tuzikov, Sharipov and Surin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuronal ion homeostasis is supported by activity of various protein molecules located in the plasma membrane: ion channels, pumps, secondary transporters. The interaction of LPS with TLR4 can activate intracellular cascades leading to inflammation (black dotted arrows). Concerning the amphiphilic properties LPS is able to influence the rheological properties of plasmalemma and the protein molecules located in it. Our data demonstrates that such effects of LPS could enhance the ionic homeostasis disturbance caused by hyperstimulation of the ionotropic receptors of Glu in case of Ischemia or TBI (red arrows).