Table 1.
The role of miR-1301 in various tumors.
| System | Tumor type | Clinical samples | Cell lines | Animals | Expression | Regulatory mechanism | Effect in vitro | Effect in vivo | Ref. |
|---|---|---|---|---|---|---|---|---|---|
| Digestive system | EC | 50 pairs of tissues (From 50 patients) | EC: OE19, KYSE410, EC109, and TE11; Normal: HEEC | nude mice (female, 4 weeks old) |
Downregulation | circ_0004370/miR-1301-3p/COL1A1 | proliferation↓ migration↓ invasion↓ EMT↓ apoptosis↑ | tumor growth↓ (tumor volume and weight↓) | (10) |
| ESCC | 40 pairs of tissues (From 40 patients) | ESCC: Eca109, KYSE70, and TE-1; Normal: HEEC | – | Downregulation | LINC01433/miR-1301-3p | proliferation↓ migration↓ invasion↓ | – | (11) | |
| – | ESCC: EC9706, EC1, EC109, and KYSE150; Normal: Het-1A | 6 BALB/c nude mice (female) | Downregulation | SOX2/MIAT/miR-1301-3p/INCENP | proliferation↓ migration↓ invasion↓ | tumor growth↓ | (12) | ||
| OSCC | 30 pairs of tissues (From 30 patients) | OSCC: HSC-3 and HSC-4; Normal: NOK | – | Downregulation | LINC01207/miR-1301-3p/LDHA | proliferation↓ migration↓ invasion↓ apoptosis↑ autophagy↑ | – | (13) | |
| GC | 60 pairs of tissues (From 60 patients) | GC: MGC-803 and SGC-7901; Normal: GES-1 | 30 BALB/c nude mice (4 weeks old) |
Upregulation | miR-1301-3p/SIRT1 | proliferation↑ cell cycle↑ | tumor growth↑ (tumor volume and weight↑) | (14) | |
| 76 pairs of tissues (From 76 patients) | GC: MGC-803, HGC-27, MKN-45, and BGC-823; Normal: GES-1 | 6 BALB/c nude mice (6 weeks old) |
Downregulation | CTCF/LINC01207/miR-1301-3p/PODXL | proliferation↓ migration↓ invasion↓ apoptosis↑ | tumor growth↓ (tumor growth rate↓ tumor volume and weight↓) | (15) | ||
| CRC | – | CRC: LoVo and SW480 | – | Downregulation | miR-1301-3p/STAT3/MMPs | migration↓ invasion↓ | – | (16) | |
| 76 pairs of tissues (From 76 patients) | CRC: HCT116, SW480, Caco-2 and PKR Normal: NCM460 |
6 BALB/c nude mice (female, 5 weeks old) | Downregulation | RUNX1/RNCR3/miR-1301-3p/AKT1 | proliferation↓ invasion↓ apoptosis↑ | tumor growth↓ (tumor volume and weight↓) | (17) | ||
| 113 patients | – | – | Downregulation | miR-1301-3p/B7-H3 | migration↓ invasion↓ | tumor metastasis↓ | (4) | ||
| Colon adenocarcinoma | 36 pairs of tissues (From 36 patients) | Colon adenocarcinoma: DLD1, SW620, SW480, and HCT116; Normal: FHC |
– | Downregulation | VPS9D1-AS1/miR-1301-3p/CLDN1 | proliferation↓ migration↓ invasion↓ apoptosis↑ | – | (18) | |
| HCC | 35 pairs of tissues (From 35 patients) | HCC: Huh-7, HepG2, Hep3B, PLC/PRF/5 and Bel-7404; Normal: MIHA | – | Upregulation | miR-1301-3p/KLF6-FL | migration↑ angiogenesis↑ | – | (19) | |
| – | HCC: Huh-7, HepG2, Hep3B, MHCC97L, and SMCC-7721; Normal: LO2 | 12 BALB/c mice | Downregulation | LINC01433/miR-1301-3p/STAT3 | proliferation↓ migration↓ invasion↓ | tumor growth↓ (tumor volume and weight↓) | (20) | ||
| 60 pairs of tissues (From 60 patients) | HCC: Huh-7, HepG2, Hep3B, and SMMC-7721; Normal: LO2 | 30 BALB/c nude mice (female, 4 weeks old) | Downregulation | miR-1301-3p/BCL9 | migration↓ invasion↓ angiogenesis↓ EMT↓ | tumor metastasis↓ | (21) | ||
| – | HCC: HepG2; Normal: Qsg7701 | – | Downregulation | – | proliferation↓ migration↓ invasion↓ apoptosis↑ | – | (22) | ||
| Respiratory system | LSCC | – | LSCC: FD-LSC-1 and TU-177; Normal: HOK | – | Downregulation | PVT1/miR-1301-3p/MBNL1 | proliferation↓ apoptosis↑ susceptibility to NK cells↑ | – | (23) |
| NSCLC | 124 pairs of tissues (From 124 patients) | NSCLC: A549, H1299, MRC5, and SK-LU-1; Normal: BEAS-2B | – | Upregulation | miR-1301-3p/Thy-1 | proliferation↑ migration↑ invasion↑ | – | (3) | |
| Lung cancer | 40 pairs of tissues (From 40 patients) | Lung cancer: A549 and H1299; Normal: BEAS-2B | – | Upregulation | miR-1301-3p/PTRF | proliferation↑ migration↑ EMT↑ | – | (24) | |
| Endocrine system | PTC | 30 pairs of tissues (From 30 patients) | PTC: TPC-1, SW579, FTC133, MDA-T32, MDA-T120 and XTC-1; Normal: Nthy-ori3-1 | – | Downregulation | circ_0067934/miR-1301-3p/HMGB1 | proliferation↓ migration↓ invasion↓ EMT↓ apoptosis↑ | – | (23) |
| 70 pairs of tissues [From 70 patients with PTC (n = 35) and benign tumors (n = 35)] | PTC: TPC-1; Normal: Nthy-ori3-1 | – | Downregulation | – | proliferation↓ cell cycle↓ | – | (5) | ||
| 82 pairs of tissues (From 82 patients) | PTC: BCPAP and K1; Normal: Nthy-ori 3-1 | 12 BALB/c nude mice (male, 4-5 weeks old) | Downregulation | ABHD11-AS1/miR-1301-3p/STAT3 | proliferation↓ migration↓ invasion↓ EMT↓ apoptosis↑ | tumor growth↓ (tumor volume and weight↓) tumor metastasis↓ |
(25) | ||
| Urinary system | ccRCC | 45 pairs of tissues (From 45 patients) | ccRCC: A498, 786-O, Caki-1, and OSRC-2; Normal: HK2 | – | Downregulation | SNHG16/miR-1301-3p/STARD9 | proliferation↓ apoptosis↑ | – | (26) |
| BCa | – | BCa: RT-4, UM-UC-3, J82, and T24; Normal: SV-HUC-1 | – | Downregulation | NNT-AS1/miR-1301-3p/PODXL | proliferation↓ migration↓ invasion↓ EMT↓ apoptosis↑ | – | (27) | |
| Reproductive system | CC | – | CC: DoTc2 4510, HCC94, C-33A, and HT3; Normal: Ect1/E6E7 | – | Downregulation | MYLK/miR-1301-3p/RHEB | proliferation↓ apoptosis↑ | – | (28) |
| BC | 8 pairs of tissues (From 8 patients) | BC: MCF-7, MDA-MB231, T47D, MDA-MB453, SKBR3, BT549, MDA-MB435, ZR-75-30, and Bcap37; Normal: 2 primary normal breast epithelial cells | – | Upregulation | miR-1301-3p/ICAT | proliferation↑ | – | (1) | |
| TNBC | – | TNBC: MDA-MB231, SUM149PT, HCC1937, and HCC1806 | 12 nude mice (female) |
Upregulation | EZH2/miR-1301-3p/EZH2 | proliferation↓ migration↓ invasion↓ | tumor growth↓ (tumor volume and weight↓) | (29) | |
| Prostate cancer | 8 pairs of tissues (From 8 patients) | – | – | Upregulation | miR-1301-3p/SFRP1, GSK3β | self-renewal of PCSCs↑ | – | (30) | |
| 8 pairs of tissues (From 8 patients) | Prostate cancer: Tsu-Pr1, PC3, DU145, LNCaP, and 22RV1; Normal: prostate epithelial cells | – | Upregulation | miR-1301-3p/PPP2R2C | proliferation↑ cell cycle↑ | – | (31) | ||
| Number not shown | LNCaP and MDAPCa2b | Downregulation | miR-1301-3p/UBE4B | proliferation↓ cell cycle↓ migration↓ invasion↓ apoptosis↑ | – | (32) | |||
| Nervous system | Glioma | 184 patients | – | – | Downregulation | – | – | – | (2) |
| GBM | 6 non-cancerous brain tissues and 33 glioma tissues(low grade = 15, high grade = 18) (From 39 patients) |
GBM: U87, U251, U118, LN229, A172, and H4; Normal: NHA | 10 BALB/c nude mice (female, 4 weeks old) | Downregulation | miR-1301-3p/N-Ras | proliferation↓ cell cycle↓ | tumor growth↓ | (33) | |
| – | GBM: U87, U251, and T98G; Normal: NHA | nude mice (male) |
Downregulation | PVT1/miR-1301-3p/TMBIM6 | proliferation↓ invasion↓ apoptosis↑ | tumor growth↓ | (34) | ||
| Others | OS | – | OS: U2OS and SAOS-2; Normal: hFOB1.19 | – | Downregulation | miR-1301-3p/TRIAP1 | proliferation↓ apoptosis↑ | – | (7) |
| – | OS: U2OS and MG-63 | – | Downregulation | SNHG16/miR-1301-3p/BCL9 | proliferation↓ migration↓ invasion↓ | – | (35) | ||
| 65 pairs of tissues (From 65 patients) | OS: U2OS, MG-63, SW1353, SAOS-2, and HOS; Normal: hFOB1.19 | – | Downregulation | miR-1301-3p/BCL9 | proliferation↓ migration↓ invasion↓ | – | (6) | ||
| CML | 4 blood samples | CML: K562 and KU812; Normal: granulocytes and monocytes | – | Downregulation | miR-1301-3p/RanGAP1 | – | – | (8) |
EC, esophageal cancer; ESCC, esophageal squamous cell carcinoma; OSCC, oral squamous cell carcinoma; GC, gastric cancer; CRC, colorectal cancer; HCC, hepatocellular carcinoma; LSCC, Laryngeal squamous cell carcinoma; NSCLC, Non-small cell lung cancer; PTC, papillary thyroid carcinoma; ccRCC, clear cell renal cell carcinoma; CC, cervical cancer; BC, breast cancer; TNBC, triple negative breast cancer; GBM, glioblastoma multiforme; OS, osteosarcoma; CML, chronic myeloid leukemia.