Table 2. Effects of the intervention on the use of PIM and neuroleptic drugs at 6 months following inclusion.
| Study participants | Nursing home residents with ≥ 1 PIM and/or ≥ 2 neuroleptics |
Mixed model 1*1
OR [95% CI] (unadjusted) (p) |
Mixed model 2*2
OR [95% CI] (adjusted) (p) |
|
|
Intervention group
n (%) |
Control group
n (%) |
|||
| ITT (n = 773) | 162 (40.6 %) |
151 (40.4 %) |
1.05 [0.68; 1.62] (p = 0.836) |
0.90 [0.55; 1.46] (p = 0.762) (32 missing) |
| PP (n = 647) | 130 (41.0 %) |
133 (40.3 %) |
1.04 [0.64; 1.69] (p = 0.864) |
0.78 [0.42; 1.42] (p = 0.409) (6 missing) |
*1 The homes are included in the analysis as a cluster or random effect. ICC for ITT = 0.073; ICC for PP = 0.089
*2 The homes are included in the analysis as a cluster or random effect. Adjusting variables include: age, sex, dementia, number of diseases, use of ≥ 1 PIM and/or ≥ 2 neuroleptic drugs at baseline
IICC, intraclass correlation; ITT, intention-to-treat analysis; OR, odds ratio; PIM, potentially inadequate medications; PP, per-protocol analysis; 95% CI, 95% confidence interval