Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 5;11:789659. doi: 10.3389/fonc.2021.789659

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Tran, Nguyen, Pham, Phan, Nguyen, Nguyen, Nguyen, Doan, Le, Nguyen, Jasmine, Nguyen, Nguyen, Nguyen, Do, Tran, Nguyen, Le, Nguyen, Do, Truong, Tang, Phan, Nguyen, Giang and Tu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Pathogenic variants associated with Hereditary Colorectal Cancer syndromes. (A) Percentage of participants positive for at least one pathogenic variant in the genes associated with Hereditary Colorectal Cancer Syndromes (HCCS): Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM), familial adenomatous polyposis (FAP) (APC), MUTYH-associated adenomatous polypopsis (MAP) (MUTYH). The percentage of carriers by gender and number of variants was also illustrated. (B) Pie chart showing the distribution of pathogenic variants among the HCCS-associated genes. No variant was found in EPCAM and MSH2. (C) Lollipop plot reporting distribution of all pathogenic variants identified in MSH6. Protein domains shown include PWWP (Pro-Trp-Trp-Pro) and all Mutator S (MutS) domains.