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The percentage of carriers for pathogenic variants associated with specific hereditary cancer syndromes.
| All (n = 1165) | With Hx (n = 403) | No Hx (n = 762) | ||
|---|---|---|---|---|
| HCCS | All associated genes | 1.3% | 1.5% | 1.0% |
| Lynch | MLH1, MSH2, MSH6, PMS2, EPCAM | 0.8% | 0.5% | 0.9% |
| FAP | APC | 0.3% | 0.3% | 0.3% |
| MAP | MUTYH | 0.3% | 0.5% | 0.1% |
| HBOC | All associated genes | 1.6% | 1.5% | 1.7% |
| BRCA1/2 | 1.3% | 1.5% | 1.2% | |
| Others (PALB2, TP53) | 0.3% | 0% | 0.5% |
Hx: family or personal history of cancer.
