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. Author manuscript; available in PMC: 2022 Jan 19.
Published in final edited form as: Br J Pharmacol. 2020 Aug 13;178(16):3220–3234. doi: 10.1111/bph.15209

Figure 4.

Figure 4.

HPCD treatment by subcutaneous injections: effects on retinal cholesterol of Cyp27a1−/−Cyp46a1−/− mice. Dots represent individual measurements in mouse retina (5–8 mice per group). The total cholesterol content is a sum of the esterified and unesterified cholesterol. Statistical significance for changes in total cholesterol in HPCD-treated vs control mice was assessed by the Mann-Whitney U test. *P ≤ 0.05. 2x, 2 injections; 3x, three injections; Cntrl, control mice; BW, body weight; Tx, HPCD-treated mice.