Table 1.

Retinal proteins with differential abundance (≥1.5-fold) in the HPCD-treated (Tx) vs control (Cntr) WT mice. Protein grouping is by process and shows each protein only in one group despite the involvement in multiple processes. Proteins with a decreased expression are in bold.

Protein	№ of Peptides with Significant Changes in Abundance	№ of Unique Peptides	Sequence Coverage (%)	Peptide Intensity (a.u.) × 106		Tx/Cntr, Protein Ratio
				Tx	Cntr
Vesicular Transport and Cytoskeletal Organization
AT10A	2	2	1	0.29 ± 0.03	0.06 ± 0.01	4.8
CA2D2	2	2	3	0.02 ± 0.04	0.28 ± 0.09	0.1
DMXL2	20	17	13	0.60 ± 0.1	0.96 ± 0.06	0.6
K2C1	8	3	7	2.98 ± 0.75	1.73 ± 0.23	1.7
KLC1	2	2	5	0.27 ± 0.02	0.17 ± 0.05	1.6
LRP1	2	2	1	0.17 ± 0.06	0.39 ± 0.03	0.4
LZTL1	3	3	14	0.25 ± 0.08	0.43± 0.04	0.6
M4K2	3	2	2	1.56 ± 0.07	0.60 ± 0.28	2.6
OPTN	3	3	7	0.18 ± 0.01	0.32 ± 0.07	0.5
TMED2	2	2	7	0.37 ± 0.02	0.21 ± 0.09	1.7
TPPP3	4	4	22	0.49 ± 0.16	0.78 ± 0.05	0.6
Metabolism and Energy Homeostasis
AL3A1	7	5	23	0.29 ± 0.17	0.63±0.01	0.5
COX6	3	3	29	2.56 ± 0.20	1.72 ± 0.36	1.5
DCUP	2	2	13	0.00 ± 0.00	0.13 ± 0.05	Cntr only
HEMO	2	2	8	0.41 ± 0.03	0.20 ± 0.09	2.0
MIC27	3	3	14	0.46 ± 0.11	0.11 ± 0.12	4.1
NLTP	4	4	9	0.87 ± 0.11	0.43 ± 0.1	2.0
NDUA7	2	2	18	0.47 ± 0.10	0.24 ± 0.04	2.0
Genetic Information Transfer
HDGR2	8	5	12	0.40 ± 0.05	0.24 ± 0.08	1.7
RPL23A	3	3	17	1.38 ± 0.20	0.93 ± 0.07	1.5
RS26	2	2	19	0.47 ± 0.10	0.29 ± 0.03	1.6
SYRC	2	2	4	0.42 ± 0.04	0.24 ± 0.09	1.7
Ubiquitin-Proteasome System and Protein Folding
CCD47	2	2	9	0.04 ± 0.03	0.95 ± 0.01	0.4
PSB3	4	4	29	1.35 ± 0.32	2.02 ± 0.20	0.1
PSMD6	2	2	6	0.46 ± 0.07	0.18 ± 0.05	2.4
UBE3A	2	2	4	0.09 ± 0.01	0.26 ± 0.05	0.4
Cell Survival and Signaling
CPNE3	4	3	11	0.48 ± 0.09	0.25 ± 0.05	1.9
MANF	2	2	18	0.38 ± 0.1	0.59± 0.06	0.7
MLF2	2	2	11	0.37 ± 0.08	0.15 ± 0.08	2.4
SH3L1	3	3	38	1.19 ± 0.11	0.61 ± 0.27	2.0