Table 1.

Main characteristics of the eligible studies.

Study	No. patients	Interventions	Period	Region, center	Inclusion criteria	Exclusion criteria	Follow-up period, years
Di Mario et al. (5)	69	Immediate CR vs. COR	NA	UK/Italy, multi	STEMI with multivessel disease; 1~3 lesions in non-IRA amenable to treated with stent	CS; LM disease; ≥1 CTOs; diffuse calcification or severe tortuosity; <1 week thrombosis; vein grafts, arterial conduits or restenotic lesion	1
Wald et al. (9)	465	Immediate CR vs. COR	2008–2013	UK, multi	STEMI with ≥50% stenosis of ≥1 non-IRAs	CS; LM disease; previous CABG; CTO as the only non-IRA; unable to provide consent	1.9 (mean)
Smits et al. (12)	885	Immediate CR vs. COR	2011–2015	8 countries, multi	STEMI with ≥50% stenosis of ≥1 non-IRAs (or their major side branches of ≥ 2.0 mm)	LM disease; CTO; severe stenosis; TIMI flow ≥ 2 in non-IRA; suboptimal result or complications after IRA PCI; severe valve dysfunction; Killip class ≥ III	1
Ghani et al. (7)	121	Staged CR before discharge or within 3 weeks after STEMI vs. COR	2004–2007	Netherlands, single	STEMI with ≥50% stenosis of ≥2 epicardial arteries, or the combination of a side branch and a main epicardial vessel (≥2.5mm)	Urgent indication for additional revascularization; > 80 years old; CTO; previous CABG; LM disease; restenotic lesions in non-IRAs; chronic atrial fibrillation; limited life-expectancy	3
Engstrom et al. (11)	627	Staged CR 2 days after primary PCI before discharge vs. COR	2011–2014	Denmark, multi	STEMI with >50% in ≥1 non-IRAs	Intolerance of contrast media or of relevant anticoagulant or antithrombotic drugs; unconsciousness or CS; ST; indication for CABG; increased bleeding risk	2.3
Hlinomaz et al. (25)	214	Staged CR 3~40 days after primary PCI vs. COR	2009-2013	Czech/Bulgaria, multi	STEMI with ≥70% in ≥1 non-IRAs (≥2.5mm)	CS; LM disease; hemodynamic instability; significant valvular disease; angina pectoris > grade 2 CCS lasting 1 month	3.2
Mehta et al. (18)	4041	Staged CR before discharge or within 45 days after randomization vs. COR	2013-2017	31 countries, multi	STEMI with visually ≥70% or 50~69% with FFR ≤ 0.8 in ≥1 non-IRAs (≥2.5mm)	Intention before randomization to revascularize a nonculprit lesion; planned surgical revascularization; previous CABG; life expectancy <5 year	3
Ochala et al. (23)	92	Immediate CR vs. Staged CR 27 days after primary PCI	NA	Poland, multi	STEMI with >70% in ≥1 non-IRAs	CS; LM disease; previous CABG; target lesion in non-IRA not suitable for PCI; renal insufficiency or presence of 1 kidney; contraindications for antiplatelet therapy; valvular disease requiring surgery	0.5
Maamoun et al. (24)	78	Immediate CR vs. Staged CR within 7 days after primary PCI	2007-2008	Yemen, single	STEMI with ≥70% stenosis of ≥2 angiographically-documented diseased arteries	CS; LM disease; pulmonary edema; previous revascularization; serum creatinine >1.4 mg/dl; contraindication for antiplatelet therapy	1
Tarasov et al. (26)	136	Immediate CR vs. Staged CR 10 days after primary PCI before discharge	2011-2014	Russia, single	STEMI with visually≥70% stenosis of ≥2 epicardial arteries or significant branches (≥2.5mm)	CS; LM disease; contraindication to use heparin, aspirin, clopidogrel, ticagrelor, zotarolimus	1
Politi et al. (6)	214	Immediate CR vs. COR vs. Staged CR 57 days after primary PCI	2003-2007	Italy, single	STEMI with visually>70% stenosis of ≥2 epicardial arteries or their major branches	CS; LM disease; previous CABG; severe valvular disease; unsuccessful procedures	2.5 (mean)

CABG, coronary artery bypass grafting; CCS, Canadian Cardiovascular Society; CTO, chronic total occlusion; COR, culprit-only revascularization; CR, complete revascularization; CS, cardiogenic shock; IRA, infarct-related artery; LM, left main; NA, not applicable; PCI, percutaneous coronary intervention; STEMI, ST segment elevation myocardial infarction.