Table 3.

S-Methadone parameters.

PHARMACOKINETIC PARAMETERS

Parameter	Estimate	RSE %	95 % CI	Bootstrap 50^th %ile	Bootstrap 2.5–97.5%ile CI

CL (L/hr) HIV-	6.91	3.4 %	6.46–7.37	6.90	6.46–7.36
CL (L/hr) HIV+ ART-	9.41	9.2 %	7.71–11.1	9.40	7.88–11.40
CL (L/hr) HIV+ EFV+	18.9	5.1 %	17.0–20.8	19.00	16.93–21.14
CL (L/hr) HIV+ NVP+	27.9	5.2 %	25.1–30.7	27.84	24.95–30.10
CL (L/hr) NR1I3 8784 with EFV	8.29	7.0 %	7.19–9.40	8.22	7.05–9.60
CL (L/hr) CYP2B6 785G	5.67	3.6 %	5.27–6.06	5.69	5.29–6.08
VC (L) HIV-	205	3.0 %	193–217	205	195–219
V (L) HIV+	285	4.1 %	262–308	287	262–310

Random Effects	Estimate	RSE %	Shrinkage (%)	Bootstrap 50^th %ile	Bootstrap 2.5–97.5%ile CI

BETWEEN SUBJECT VARIABILITY (BSV)
BSV CL	37.9 %	5.1 %	6.5 %	39.0 %	35.0–43.8 %
BSV V	30.8 %	6.4 %	15 %	31.1 %	27.1–35.7 %
CL,V correlation (r)	0.727	6.8 %	-	0.731	0.691–0.758
BOV CL	16.3 %	6.3 %	37 %	16.3 %	14.3–18.4 %
RESIDUAL UNEXPLAINED VARIABILITY (RUV)
RUV	17.8 %	4.8 %	27.5 %	17.7 %	16.1–19.4 %

RSE%: % relative standard error; BOV: between occasion variability; CI: confidence interval.