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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Curr Protoc. 2021 Feb;1(2):e16. doi: 10.1002/cpz1.16

Figure 2: Tissue specific protein degradation in C. elegans.

Figure 2:

Expression of TIR1 in specific tissues can allow tissue specific degradation of proteins. Some examples of tissue specific degradation upon addition of auxin are diagrammed in C. elegans, wherein green represents regions where the degron-tagged protein continues to be expressed and white represents regions where the degron-tagged protein is degraded due to expression of TIR1 in that tissue. The table highlights some of the tissues in which TIR1 has been successfully expressed, as well as the corresponding tissue-specific promoters that have been used and developed in the field for degron studies thus far (Ashley et al., 2020; J. Chen et al., 2020; Kasimatis et al., 2018; Wirshing & Cram, 2018; Zhang et al., 2015).