TABLE 2.
Geometric mean MICs by three methods and mean zone diameters for four antibiotics on multiple media against 206 strains of H. influenzae
| Antimicrobial agent | Geometric mean MIC (μg/ml) under the following conditions:
|
Mean zone diam (mm) by DD method (CO2)
|
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMDa (air)
|
AD method (CO2)
|
Etest (CO2)
|
||||||||||||||||||
| HTM | LHB-3 | HTM | LHB-5 | WHB | HGB | FIL | ISO | HTM | LHB-5 | WHB | HGB | FIL | ISO | HTM | LHB-5 | WHB | HGB | FIL | ISO | |
| Telithromycin | 1.87 | 1.69 | 1.34 | 2.44 | 2.29 | 3.02 | 1.92 | 2.00 | 4.06 | 4.60 | 4.49 | 5.91 | 3.65 | 3.82 | 19.6 | 19.2 | 19.2 | 17.8 | 20.7 | 20.4 |
| Clarithromycin | 8.61 | 7.13 | 5.35 | 8.54 | 8.02 | 8.07 | 6.22 | 7.05 | 8.50 | 10.3 | 9.72 | 10.3 | 7.61 | 8.52 | 16.5 | 16.0 | 16.2 | 16.0 | 17.7 | 17.2 |
| Azithromycin | 1.23 | 1.17 | 1.49 | 1.93 | 1.98 | 2.01 | 1.34 | 1.48 | 3.86 | 6.67 | 3.70 | 4.11 | 2.83 | 2.96 | 20.1 | 20.9 | 20.5 | 20.9 | 22.6 | 21.8 |
| Ampicillin | 2.49 | 2.55 | 1.91 | 2.42 | 3.00 | 3.60 | 2.57 | 2.23 | 1.23 | 1.62 | 1.53 | 1.65 | 1.26 | 1.64 | 21.6 | 20.8 | 20.5 | 20.4 | 21.8 | 21.1 |
a
BMD tests in two broth media (Table 1).