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. 2022 Jan 19;3(2):104–118.e4. doi: 10.1016/j.medj.2021.12.004

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© 2021 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Vaccinated individuals and immune characterization

(A) Immune characterization was done in six cohorts: single-dose Ad26.COV2.S (J), double-dose Ad26.COV2.S (J+J), heterologous Ad26.COV2.S + BNT162b2 (J+P), single-dose BNT162b2 (P), and double-dose BNT162b2 (P+P). Unvaccinated cohort was used as a control (Unvac). The number of individuals for each cohort, the interval between first and second dose of vaccine, and the range of days for blood collection after last dose of vaccine are indicated. Sampling for immune analysis (humoral and cellular) was done only after the last vaccination dose both in homologous and heterologous vaccinated groups.

(B) Schematic of humoral and cellular analysis.

(C) Schematic representation of the location of the seven Spike-specific peptide pools containing 15-mer overlapping peptides spanning the entire Spike protein. Pools 1 to 4 contain peptides from the signal peptide and the S1 chain. Pools 5 to 7 encompass the S2 chain together with the transmembrane and cytoplasmic domains.

See also Figure S1.