Table 3.
Baseline predictors for progression to IA in anti-CCP− individuals
| Predictor | Non-progressors (n = 5587) | Progressors to IA (n = 53) | Univariable OR (95% CI) P-value |
Multivariable OR (95% CI) P-value |
|---|---|---|---|---|
| Mean age (SD; range) | 53 (14.7; 16–91) | 60 (13.62; 30–82) | 1.04 (1.02–1.06) P < 0.001 | 1.04 (1.02–1.07) P < 0.001 |
| Female (%) | 72 | 58 | 0.54 (0.31–0.94) P = 0.030 | 0.67 (0.35–1.28) P = 0.229 |
| Family with RA (%) | 38 | 33 | 0.758 (0.42–1.35) P = 0.349 | 1.14 (0.59–2.19) P = 0.683 |
| Ever smoked (%) | 38 | 43 | 1.25 (0.69–2.28) P = 0.462 | 1.11 (0.60–2.05) P = 0.730 |
| Neck (%) | 30 | 29 | 1.03 (0.57–1.8) P = 0.932 | 0.62 (0.29–1.30) P = 0.202 |
| Shoulders (%) | 41 | 59 | 1.99 (1.15–3.45) P = 0.014 | 1.95 (0.98–3.86) P = 0.056 |
| Elbows (%) | 29 | 40 | 1.58 (0.91–2.75) P = 0.104 | 1.32 (0.67–2.59) P = 0.413 |
| Wrists (%) | 38 | 47 | 1.43 (0.83–2.46) P = 0.193 | 1.18 (0.60–2.31) P = 0.625 |
| Hands (%) | 53 | 76 | 2.67 (1.43–5.02) P = 0.002 | 2.51 (1.17–5.39) P = 0.018 |
| Thumbs (%) | 36 | 49 | 1.70 (0.99–2.92) P = 0.054 | 1.23 (0.63–2.41) P = 0.541 |
| Back (%) | 33 | 25 | 0.66 (0.35–1.23) P = 0.190 | 0.66 (0.31–1.41) P = 0.279 |
| Hips (%) | 36 | 28 | 0.69 (0.38–1.26) P = 0.226 | 0.57 (0.28–1.17) P = 0.127 |
| Knees (%) | 55 | 72 | 2.07 (1.14–3.77) P = 0.018 | 3.03 (1.47–6.25) P = 0.003 |
| Ankles (%) | 30 | 23 | 0.68 (0.36–1.29) P = 0.239 | 0.55 (0.25–1.21) P = 0.140 |
| Feet (%) | 34 | 42 | 1.37 (0.79–2.38) P = 0.256 | 1.04 (0.52–2.06) P = 0.910 |