Table 2.
Characterization of OXA-48 carbapenemase-producing Klebsiella pneumoniae strains from geriatric outpatients
| No | Strain number | Age/ gender | CZ | CXM | CAZ | CTX | CRO | FEP | IMI | MEM | GM | CIP | COL | FOS | SXT | ESBL | MHT | CIM | ESBL | IS1999 | P/ST |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
K1 4229/2–18 |
85/F | > 128 | > 128 | 16 | > 128 | > 128 | 16 | 2 | 2 | > 128 | > 128 | > 128 | 32 | R | + | + | + |
CTX-M gr. 1 |
+ | L,FIIs |
| 2 |
K5 12,944/2–18 |
75/M | > 128 | > 128 | 64 | > 128 | > 128 | 16 | 1 | 2 | 0.25 | 0.5 | 0.5 | 32 | S | + | + | + | CTX-M gr. 1 | + | FIIs |
| 3 |
K6 9057/2–18 |
87/M | > 128 | > 128 | > 128 | > 128 | > 128 | 64 | 0.5 | 1 | 2 | 2 | 0.5 | 64 | S | + | + | + | CTX-M gr. 1 | + | L,FIIs |
| 4 |
K7 33,497/2–18 |
83/M | > 128 | > 128 | 32 | > 128 | > 128 | 8 | 1 | 0.5 | > 128 | 0.5 | 32 | 64 | R | + | + | + | CTX-M gr. 1 | + | L,FIIs |
| 5 |
K10 25,085/2–18 |
84/F | > 128 | > 128 | 64 | > 128 | > 128 | 16 | 0.12 | 2 | 0.5 | > 128 | 0.5 | > 256 | R | + | + | + | CTX-M gr. 1 | + | L,FIIs |
| 6 |
K11 48,065/2–18 |
70/F | > 128 | > 128 | > 128 | > 128 | > 128 | 16 | 2 | 8 | > 128 | 4 | 0.5 | > 256 | R | + | + | + | CTX-M gr. 1 | - | FIIs |
| 7 |
K16 58,160/2–18 |
81/M | > 128 | > 128 | 64 | > 128 | > 128 | 16 | 1 | 1 | 0.5 | > 128 | 0.5 | 16 | R | + | + | + | CTX-M gr. 1 | - | |
| 8 |
K26 9938/2–18 |
87/M | > 128 | > 128 | 32 | > 128 | > 128 | 16 | 0.25 | 2 | 2 | > 128 | 0.5 | 256 | R | + | + | + | CTX-M gr. 1 | - | L,FIIs |
| 9 |
K27 50,638/2–17 |
76/F | > 128 | > 128 | 64 | > 128 | > 128 | 16 | 0.25 | 0.5 | 8 | > 128 | 0.12 | 128 | R | + | + | + | CTX-M gr. 1 | - | L |
| 10 |
K32 62,774/2–17 |
77/F | > 128 | > 128 | 64 | > 128 | > 128 | 16 | 1 | 0.5 | 16 | 4 | 0.25 | 256 | R | + | + | + | CTX-M gr. 1 | - |
L, Col, FIB, FII /ST29 |
| 11 |
K35 43,400/2–18 |
66/M | 2 | 8 | 0.25 | 0.12 | 0.12 | 0.25 | 1 | 2 | 16 | 4 | 0.12 | 256 | R | - | + | + | - | - | L |
| 12 |
K36 6103/2–17 |
84/M | > 128 | > 128 | 0.5 | 0.12 | 0.12 | 0.5 | 1 | 4 | 128 | 8 | 0.25 | > 256 | R | - | + | + | - | - | L |
| 13 |
K39 51,869/2–16 |
91/M | > 128 | > 128 | > 128 | > 128 | 64 | 8 | 1 | 2 | 0.06 | 4 | 0.5 | > 256 | R | + | + | + | SHV-12 | - | L, FIIs |
| 14 |
K44 66,350/2–16 |
72/M | > 128 | > 128 | 0.5 | 0.25 | 0.25 | 0.5 | 4 | 4 | 0.25 | 8 | 0.25 | 256 | R | - | - | + | - | - | |
| 15 |
K48 37,545/2–16 |
77/F | > 128 | > 128 | > 128 | > 128 | 64 | 16 | 2 | 2 | 0.5 | > 128 | 0.5 | > 256 | R | + | + | + | CTX-M gr. 1 | - | L |
| 16 |
K49 5376/2–16 |
69/M | > 128 | > 128 | > 64 | > 128 | 64 | 8 | 2 | 4 | 1 | 4 | 16 | > 256 | S | + | - | + | CTX-M gr. 1 | - | |
| 17 |
K50 27,771/2–17 |
73/M | > 128 | > 128 | 1 | 2 | 0.5 | 0.5 | 0.25 | 2 | 0.06 | > 128 | 0.5 | > 256 | S | - | - | + | - | - | |
| 18 |
K53 45,871/2–16 |
75/F | > 128 | > 128 | 64 | > 128 | > 128 | 32 | 4 | 8 | 16 | > 128 | 0.5 | > 256 | R | + | + | + | CTX-M gr. 1 | + | L/ST437 |
| 19 |
K55 57,452/2–17 |
83/M | > 128 | > 128 | 0.25 | 2 | 0.5 | 0.12 | 2 | 2 | 0.25 | > 128 | 0.25 | > 256 | S | - | - | + | - | + | L/ST727 |
| 20 |
K56 56,540/2–18 |
68/M | > 128 | > 128 | 64 | > 128 | > 128 | 32 | 1 | 2 | > 128 | > 128 | 0.12 | > 256 | R | + | + | + | CTX-M gr. 1 | + | L/ST4870 |
| 21 |
K64 37,429/2–16 |
68/F | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | 2 | 1 | 1 | 16 | 0.12 | 128 | S | + | + | + | CTX-M gr. 1 | + | |
| 22 |
K69 10,132/2–18 |
68/M | > 128 | 64 | > 128 | > 128 | > 128 | 64 | 2 | 1 | 16 | 4 | 0.12 | > 256 | S | + | + | + | CTX-M gr. 1 | + | L |
| 23 |
K71 24,329/2–18 |
63/M | > 128 | > 128 | 32 | > 128 | > 128 | 32 | 2 | 1 | 16 | 4 | 0.25 | 128 | R | + | + | + | CTX-M gr. 1 | + | |
| 24 |
K75 40,425/2–15 |
74/F | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | 4 | 8 | 32 | 2 | 0.25 | 64 | R | + | + | + | CTX-M gr. 1 | + | |
| 25 |
K77 29,303/2–17 |
61/M | > 128 | > 128 | > 128 | > 128 | > 128 | 16 | 2 | 2 | 16 | 64 | 0.12 | 256 | R | + | + | + | CTX-M gr. 1 | - | |
| 26 |
K79 56,293/2–17 |
78/F | > 128 | > 128 | 16 | 64 | 64 | 32 | 0.5 | 0.06 | 0.5 | 64 | 0.5 | 32 | R | + | + | + | CTX-M gr. 1 | + | L |
| 27 |
K83 44,694/2–18 |
64/F | > 128 | > 128 | > 128 | > 128 | > 128 | > 128 | 1 | 0.5 | 0.5 | > 128 | 1 | > 256 | R | + | + | + | CTX-M gr. 1 | + | L, FIB, FII |
| 28 |
K84 55,556/2–18 |
62/F | > 128 | > 128 | 32 | 128 | 128 | 32 | 0.5 | 0.25 | 64 | > 128 | 1 | 256 | R | + | + | + | CTX-M gr. 1 | + | L |
| 29 |
K88 43,325/2–16 |
72/M | > 128 | > 128 | 64 | 128 | 128 | 64 | 2 | 4 | 0.25 | 64 | 1 | > 256 | R | + | + | + | CTX-M gr. 1 | + | |
| 30 |
K90 40,020/2–16 |
84/M | 16 | 16 | 1 | 2 | 2 | 0.5 | 2 | 2 | 16 | 32 | 0.5 | 64 | R | - | - | + | - | - | |
| 31 |
K94 28,126/2–18 a |
65/M | > 128 | > 128 | 32 | 128 | 128 | 16 | 1 | 0.25 | 64 | 4 | 4 | 32 | R | + | + | + | CTX-M gr. 1 | + | |
| 32 |
K95 28,126/2–18 b |
65/M | 4 | 4 | 0.25 | 0.25 | 1 | 0.25 | 1 | 2 | 32 | 4 | 8 | 32 | R | - | + | + | - | + | |
| 33 |
K101 281,766 |
80/F | > 128 | > 128 | 32 | 128 | 128 | 16 | 2 | 0.5 | 1 | > 128 | 1 | 16 | R | + | + | + | CTX-M gr. 1 | + | |
| 34 |
K103 20,886 |
75/F | > 128 | > 128 | 128 | 128 | 128 | 8 | 4 | 4 | 2 | > 128 | 0.5 | 32 | R | + | + | + | CTX-M gr. 1 | + | |
| 35 |
K104 174,225 |
64/M | > 128 | > 128 | 128 | 128 | 128 | 64 | 64 | 64 | 0.25 | > 128 | 0.5 | 32 | R | + | + | + | CTX-M gr. 1 | + | |
| 36 |
K105 9497 |
90/F | 8 | 4 | 1 | 0,5 | 0,5 | 0,25 | 2 | 0,5 | 32 | 64 | 0,5 | 16 | S | - | + | + | - | - |
CZ cefazoline, CXM cefuroxime, CAZ ceftazidime, CTX cefotaxime, CRO ceftriaxone, FEP cefepime, IPM imipenem, MEM meropenem, GM gentamicin, CIP iprofloxacin, FOS fosfmoycin, COL colistin, SXT cotrimoxazole, ESBL combined disk test using cephalosporins alone and combined with clavulanate for detection of ESBLs, MHT modified Hodge test, CIM carbapenem inactivation method, P/ST plasmid Inc group and sequence type