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. 2022 Jan 19;21:24. doi: 10.1186/s12943-022-01501-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Clinical implication of the circFARP1/LIF axis in PDAC. A Representative images of ISH for circFARP1 and IHC for CAV1 and LIF in PDAC tissues. Scale bars, 100 μm. B Quantification of the percentage of specimens with low or high CAV1, miR-660-3p, and LIF in the low or high circFARP1 expression groups. C Correlation analysis of circFARP1 and LIF expression in PDAC tissues (n = 82). D-E ELISA analysis of the serum LIF level in GEM-S (n = 38) and GEM-R patients (n = 44). F Kaplan–Meier survival curves for PDAC patients who received GEM chemotherapy with high or low circFARP1 expression. G Timeline schematic for the treatment of mice with PDX. Colored arrows indicate the times at different treatment time points. H Fold changes in tumor volume and response rates in PDXs that received the indicated treatments (n = 7). The chemotherapy responses were evaluated using the RECIST standard. I Representative images of IHC for α-SMA, SOX2, ABCC2, and CDA in the PDX. Scale bars, 50 μm. J Schematic illustration of the mechanism by which circFARP1 enables CAFs to promote GEM chemoresistance in pancreatic cancer. Data are expressed as the mean ± SD. ***p<0.001