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. 2022 Jan 19;41:28. doi: 10.1186/s13046-021-02211-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Proteins/lipids related to ERRα were enriched in mitochondrial function in EC (A) The relationship between TFEB-ERRα and acc, fasn, acadm are determined by RT-qPCR in KLE and ECC-1 cells. (B) The association of oxygen consumption rates (OCR), basal, maximal respiration, spare respiratory capacity, and ATP production regulated by TFEB-ERRα are shown. (C) The effect of ERRα regulation on TFEB, LPCAT1, LPCAT3, MMP2, and Cortactin expression in EC cells is analyzed using western blot (WB). (D) The effect of XCT790 treatment on LPCAT1, LPCAT3, MMP2, and Cortactin proteins for 24 h were evaluated between control and TFEB-overexpressing by WB. (E) Representative Scanning electron microscope (SEM) micrographs of KLE and ECC-1: TFEB-ERRα axis and XCT790 treatment for 24 h regulated pseudopod, in comparison to the controlled group. Micrographs are screened at scale of 10–30 µM. *, p < 0.05. Statistical tests: Student’ s t-test or ANOVA.