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. 2022 Jan 19;41:28. doi: 10.1186/s13046-021-02211-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Accumulation of UFA-containing GPs induced by ERRα is required for EC progression (A) The baseline characteristic including BMI, menopause, FIGO stage, histologic type, MI, LNM and ERRα expression of patients (EC = 35 vs controls = 19) tissues for lipidomic. (B) Different classes of lipids were tested in 35 EC tissues and 19 control tissues. (C) Venn diagram showing the distribution of TFEB-ERRα axis related lipids and ERRα-dependent lipids in clinical samples. (D)Systematic lipidomic changes between EC and control tissues assessed by OPLS-DA. (E) Systematic lipidomic changes between LNM and non-LNM tissues assessed by OPLS-DA. (F) Significant lipid species in EC and normal control tissues and its PC/SM evaluation. (G) Analysis of TFEB-ERRα associated lipids, ERRα-dependent lipids and EC as well as LNM. (H) The univariate binary logistic regression analyses of Age, BMI, CA125, PC (18:1/18:2) + HCOO and PC (32:2) + H. (I) The correlation analysis of PC (18:1/18:2) + HCOO and ERRα. *, p < 0.05. Statistical tests: Student’ s t-test(E–F), Logistic regression(G), Pearson’s rank correlation analysis(H). BMI: Body Mass Index.