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. 2021 Oct 26;1:42. doi: 10.1038/s43856-021-00042-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Miami plot (top panel) of hypermethylated (top) and hypomethylated (bottom) probes in SARS-CoV-2+ compared to control samples. Significance lines represent FDR-adjusted P value <0.05 threshold. b Volcano plot of significant (red; FDR-adjusted P value <0.05) CpG sites (blue CpG sites have FDR-adjusted P value >0.05). Change in percentage methylation on the x axis represents the difference in average beta value at a site between cases and controls. Probes for intergenic CpG sites do not have gene annotations. Data used to plot this figure are available as Supplementary Data 5.