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. 2021 Nov 30;207(1):3–10. doi: 10.1093/cei/uxab018

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© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Immunology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3: — Immune reconstitution following CD20 depletion and vaccine responsiveness. (A) Time between last administration of anti-CD20 B-cell-depleting treatment and vaccine administration (left panel—haemato-oncology patients [red], right panel—rheumatology patients [blue]). (B) Seropositivity following SARS-CoV-2 vaccination with respect to time from last administration of anti-CD20 B-cell depletion. (C) Association between the magnitude of antibody responses and total prior exposure to anti-CD20 B-cell-depleting agents. IgGAM ratios less than 1.0 are considered negative and represented by the grey zone on the graph. (D) B-cell reconstitution and its association with vaccine responsiveness following treatment with anti-CD20 B-cell-depleting agents. Grey zones represent normal range for cellular populations.