REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-CD31 antibody	Abcam	Cat#ab28364; RRID:AB_726362
Biological samples
Patient-derived xenografts (PDX)	This study	N/A
Chemicals, Peptides, and Recombinant Proteins
MM54	Tocris Bioscience	CAS 1313027-43-8
Critical commercial assays
Cell Counting Kit-8	DOJINDO	Cat#CK04
PikoReal™Real-Time PCR System	Thermo Fisher Scientific	N/A
Deposited data
Human transcript sequences	The GENCODE Project	https://www.gencodegenes.org/human/release_27.html; RRID:SCR_014966
Mouse transcript sequences	The GENCODE Project	https://www.gencodegenes.org/mouse/release_M15.html; RRID:SCR_014966
HomoloGene build 68	(NCBI Resource Coordinators, 2016)	https://ftp.ncbi.nih.gov/pub/HomoloGene/build68/; RRID:SCR_002924
Molecular Signatures Database v6.2	(Liberzon et al., 2015)	https://www.gsea-msigdb.org/gsea/msigdb/; RRID:SCR_016863
Cancer Cell Line Encyclopedia	(Ghandi et al., 2019)	https://ocg.cancer.gov/ctd2-data-project/translational-genomics-research-institute-quantified-cancer-cell-line-encyclopedia; RRID:SCR_013836
Genotype-Tissue Expression	GTEx Consortium	https://www.gtexportal.org/home/datasets; RRID:SCR_013042
Sequence data of KIRC PDXs	(Wang et al., 2018)	EGA: EGAD00001003895
Sequence data of KIRC PDXs	(Courtney et al., 2020)	EGA: EGAD00001004799
Expression data of human and mouse genes in PDXs	This study	GEO: GSE159702
Tumor purity estimates of The Cancer Genome Atlas samples	(Aran et al., 2015)	https://gdc.cancer.gov/about-data/publications/pancanatlas
Experimental models: Cell lines
UM-RC-2	ECACC	Cat#08090511; RRID:CVCL_2739
Experimental models: Organisms/strains
Mouse: NOD.Cg-PrkdcscidIl2rgtm1Sug/ShiJic (NOD/Shi-scid,IL-2RγKO)	In-Vivo Science	RRID:MGI:6197549
Oligonucleotides
Human APJ primer, forward (CCCCTTCCTCTATGCCTTTTTC)	Eurofins Genomics	N/A
Human APJ primer, reverse (ATCTGTTCTCCACCCTTGCC)	Eurofins Genomics	N/A
Human APLN primer, forward (ACCCAAG CTGGCTAGTTAAGCCACCATGAATCT GCGGCTCTGCGTGCA)	Eurofins Genomics	N/A
Human APLN primer, reverse (TGTTCGAA GGGCCCTCTAGATCAGAAAG GCATGGGTCCCT)	Eurofins Genomics	N/A
Software and algorithms
Salmon version 0.8.1	(Patro et al., 2017)	RRID:SCR_017036
ESTIMATE version 1.0.13	(Yoshihara et al., 2013)	https://bioinformatics.mdanderson.org/estimate/
GSVA version 1.36.0	(Hänzelmann et al., 2013)	RRID:SCR_021058
Ingenuity Pathway Analysis version 01–07	QIAGEN	RRID:SCR_008653
Olympus cellSens Software	Olympus Corporation	RRID:SCR_014551
R version 4.0.0	https://www.r-project.org/	RRID:SCR_001905
Other
Resource website for codes and supplemental tables	This study	https://github.com/Kuniyo-Sueyoshi/PDX/