Table III.

Ultrasound remission in included studies

Author, year	Number of patients RA	Clinical definitions of remission	Ultrasound definitions of remission (%)
			SH + PD = 0	SH ≤ 1 and PD = 0	SH ≤ 1 and PD ≤ 1	PD = 0	PD ≤ 1	SH + tenosynovitis on B-mode and PD = 0
Saleem et al., 2011 [25]	128	DAS28 < 2.6 ≥ 6 months	17	–	56	49	78	–
Balsa et al., 2010 [26]	97	Clinician	–	–	–	57.7	–	–
Cruces et al., 2019 [29]	58	DAS28 < 2.6 ≥ 6 months	25.9	–	–	–	–	–
Peluso et al., 2011 [30]	94 Early RA: 48 Longstanding RA: 46	DAS < 1.6 ≥ 6 months	30.8 Early RA: 43.7 Longstanding RA: 17.4	–	–	–	–	–
Chung et al., 2020 [31]	97	DAS28 < 2.6	51.1	–	–	–	–	–
Saleem et al., 2009 [32]	100	DAS28 < 2.6 ≥ 6 months	TNFi + MTX: 10 DMARDs: 16	–	–	–	–	–
Horton et al., 2016 [33]	45	DAS28–CRP < 2.6	–	–	–	42	62	–
Harman et al., 2015 [34]	64	ACR/EULAR Boolean ≥ 6 months	–	–	–	–	–	bDMARD: 49.6 csDMARD: 43.9
Spinella et al., 2012 [35]	54	ACR criteria or DAS28 < 2.6 ≥ 6 months	35	–	–	–	–	–
Terslev et al., 2021 [36]	87	DAS28–CRP < 2.6 ≥ 1 year and no radiographic progression	7 bDMARD: 14 csDMARD: 0	37 40 33	–	56 55 58	–	–
Van der Ven et al., 2017 [37]	89	DAS44 ≤ 2.4 et NAG ≤ 1	–	Visit 1: 39 Visit 2: 32	–	–	–	–
Our study	37	DAS28 < 2.6 ≥ 6 months	5.4	32.4	32.4	40.5	62.2	5.4

ACR/EULAR – American College of Rheumatology/European League Against Rheumatism, CRP – C-reactive protein, DAS28 – disease activity score, DMARD – disease-modifying anti-rheumatic drugs, bDMARD – biologics, csDMARD – conventional treatment, MTX – methotrexate, PD – power Doppler, RA – rheumatoid arthritis, SH – synovial hypertrophy, TNFi – TNF inhibitor. SH + PD = 0 – the absence of synovitis on B-mode and PD, B-mode ≤ 1 and PD = 0 – a grade ≤ 1 on B-mode and a PD = 0, SH ≤ 1 and PD ≤ 1 – synovitis grade ≤ 1 on B-mode and PD, PD = 0 – the absenceof synovitis PD, PD ≤ 1 – a grade ≤ 1 of synovitis PD, SH + tenosynovitis on B-mode and PD = 0 – the absence of synovitis and tenosynovitis on B-mode and PD.