Table 1.
The top 100 cited articles in geriatric oncology
| Article | Times cited | ACI |
|---|---|---|
| 1. Hutchins LF, Unger JM, Crowley JJ, Coltman CA, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999; 341: 2061-2067. | 1511 | 68.68 |
| 2. Hurria A, Togawa K, Mohile SG, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol 2011; 29: 3457-3465. | 833 | 83.3 |
| 3. Bernabei R, Gambassi G, Lapane K, et al. Management of pain in elderly patients with cancer. JAMA 1998; 279: 1877-1882. | 736 | 32 |
| 4. Extermann M, Overcash J, Lyman GH, Parr J, Balducci L. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 1998; 16: 1582-1587. | 695 | 30.22 |
| 5. Gridelli C, Perrone F, Gallo C, et al. Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 1999; 91: 66-72. | 691 | 31.41 |
| 6. Lewis JH, Kilgore ML, Goldman DP, et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol 2003; 21: 1383-1389. | 684 | 38 |
| 7. Extermann M, Aapro M, Bernabei RB, et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol 2005; 55: 241-252. | 660 | 41.25 |
| 8. Sargent DJ, Goldberg RM, Jacobson SD, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001; 345: 1091-1097. | 618 | 30.9 |
| 9. Gridelli C, Perrone F, Gallo C, et al. Chemotherapy for elderly patients with advanced non-small-cell lung cancer: the Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst 2003; 95: 362-372. | 616 | 34.22 |
| 10. Walter LC, Covinsky KE. Cancer screening in elderly patients – a framework for individualized decision making. JAMA 2001; 285: 2750-2756. | 616 | 30.8 |
| 11. Wildiers H, Heeren P, Puts M, et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol 2014; 32: 2595-2603. | 600 | 85.71 |
| 12. Repetto L, Fratino L, Audisio RA, et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian group for geriatric oncology study. J Clin Oncol 2002; 20: 494-502. | 589 | 31 |
| 13. Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol 2007; 25: 1824-1831. | 562 | 40.14 |
| 14. Extermann M, Boler I, Reich RR, et al. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer 2012; 118: 3377-3386. | 521 | 57.89 |
| 15. Keime-Guibert F, Chinot O, Taillandier L, et al. Radiotherapy for glioblastoma in the elderly. N Engl J Med 2007; 356: 1527-1535. | 495 | 35.36 |
| 16. Diab SG, Elledge RM, Clark GM. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst 2000; 92: 550-556. | 454 | 21.62 |
| 17. Yabroff KR, Lamont EB, Mariotto A, et al. Cost of care for elderly cancer patients in the United States. J Natl Cancer Inst 2008; 100: 630-641. | 448 | 34.46 |
| 18. Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol 2004; 22: 4626-4631. | 427 | 25.12 |
| 19. Yancik R. Cancer burden in the aged – an epidemiologic and demographic overview. Cancer 1997; 80: 1273-1283. | 417 | 17.38 |
| 20. Schrag D, Cramer LD, Bach PB, Begg CB. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst 2001; 93: 850-857. | 392 | 19.6 |
| 21. Langer CJ, Manola J, Bernardo P, et al. Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: Implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J Natl Cancer Inst 2002; 94: 173-181. | 385 | 20.26 |
| 22. Simmonds P, Best L, Baughan C, et al. Surgery for colorectal cancer in elderly patients: a systematic review. Lancet 2000; 356: 968-974. | 381 | 18.14 |
| 23. Bouchardy C, Rapiti E, Fioretta G, et al. Undertreatment strongly decreases prognosis of breast cancer in elderly women. J Clin Oncol 2003; 21: 3580-3587. | 363 | 20.17 |
| 24. Owonikoko TK, Ragin CC, Belani CP, et al. Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database. J Clin Oncol 2007; 25: 5570-5577. | 353 | 25.21 |
| 25. Frasci G, Lorusso V, Panza N, et al. Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer. J Clin Oncol 2000; 18: 2529-2536. | 348 | 16.57 |
| 26. Quoix E, Zalcman G, Oster JP, et al. Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer: IFCT-0501 randomised, phase 3 trial. Lancet 2011; 378: 1079-1088. | 346 | 34.6 |
| 27. Hurria A, Gupta S, Zauderer M, et al. Developing a cancer-specific geriatric assessment – a feasibility study. Cancer 2005; 104: 1998-2005. | 344 | 21.5 |
| 28. Cunningham D, Lang I, Marcuello E, et al. Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial. Lancet Oncol 2013; 14: 1077-1085. | 337 | 42.13 |
| 29. Maione P, Perrone F, Gallo C, et al. Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the Multicenter Italian Lung Cancer in the Elderly Study. J Clin Oncol 2005; 23: 6865-6872. | 337 | 21.06 |
| 30. Kunkler IH, Williams LJ, Jack WJL, Cameron DA, Dixon JM, Investigators PI. Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial. Lancet Oncol 2015; 16: 266-273. | 333 | 55.5 |
| 31. Bluethmann SM, Mariotto AB, Rowland JH. Anticipating the “silver tsunami”: prevalence trajectories and comorbidity burden among older cancer survivors in the United States. Cancer Epidemiol Biomarkers Prev 2016; 25: 1029-1036. | 327 | 65.4 |
| 32. Goldberg RM, Tabah-Fisch I, Bleiberg H, et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol 2006; 24: 4085-4091. | 327 | 21.8 |
| 33. Biganzoli L, Wildiers H, Oakman C, et al. Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). Lancet Oncol 2012; 13: E148-E160. | 309 | 34.33 |
| 34. BallardBarbash R, Potosky AL, Harlan LC, Nayfield SG, Kessler LG. Factors associated with surgical and radiation therapy for early stage breast cancer in older women. J Natl Cancer Inst 1996; 88: 716-726. | 309 | 12.36 |
| 35. Palma D, Visser O, Lagerwaard FJ, Belderbos J, Slotman B, Senan S. Impact of introducing stereotactic lung radiotherapy for elderly patients with stage I non-small-cell lung cancer: a population-based time-trend analysis. J Clin Oncol 2010; 28: 5153-5159. | 307 | 27.91 |
| 36. Yancik R, Ries LAG. Cancer and aging in America – demographic and epidemiologic perspectives. Hematol Oncol Clin North Am 2000; 14: 17-23. | 302 | 14.38 |
| 37. Hamaker ME, Jonker JM, de Rooij SE, Vos AG, Smorenburg CH, van Munster BC. Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review. Lancet Oncol 2012; 13: E437-E44. | 295 | 32.78 |
| 38. Bellera CA, Rainfray M, Mathoulin-Pelissier S, et al. Screening older cancer patients: first evaluation of the G-8 geriatric screening tool. Ann Oncol 2012; 23: 2166-2172. | 288 | 32 |
| 39. Decoster L, van Puyvelde K, Mohile S, et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol 2015; 26: 288-300. | 285 | 47.5 |
| 40. Deimling GT, Bowman KF, Sterns S, Wagner LJ, Kahana B. Cancer-related health worries and psychological distress among older adult, long-term cancer survivors. Psychooncol 2006; 15: 306-320. | 281 | 18.73 |
| 41. Fentiman IS, Tirelli U, Monfardini S, et al. Cancer in the elderly – why so badly treated? Lancet 1990; 335: 1020-1022. | 280 | 9.03 |
| 42. Muss HB, Woolf S, Berry D, et al. Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer. JAMA 2005; 293: 1073-1081. | 279 | 17.44 |
| 43. Kudoh S, Takeda K, Nakagawa K, et al. Phase III study of docetaxel compared with vinorelbine in elderly patients with advanced non-small-cell lung cancer: results of the West Japan Thoracic Oncology Group trial (WJTOG 9904). J Clin Oncol 2006; 24: 3657-3663. | 277 | 18.47 |
| 44 . Cauley JA, Lucas FL, Kuller LH, Vogt MT, Browner WS, Cummings SR. Bone mineral density and risk of breast cancer in older women – the study of osteoporotic fractures. JAMA 1996; 276: 1404-1408. | 277 | 11.08 |
| 45. Audisio RA, Participants P, Pope D, Ramesh HSJ, Gennari R, van Leeuwen BL. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help – a SIOG surgical task force prospective study. Crit Rev Oncol Hematol 2008; 65: 156-163. | 273 | 21 |
| 46. Ramalingam SS, Dahlberg SE, Langer CJ, et al. Outcomes for elderly, advanced-stage non-small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group trial 4599. J Clin Oncol 2008; 26: 60-65. | 271 | 20.85 |
| 47. Shibata A, Paganinihill A, Ross RK, Henderson BE. Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly – a prospective-study. Br J Cancer 1992; 66: 673-679. | 266 | 9.17 |
| 48. Trimble EL, Carter CL, Cain D, Freidlin B, Ungerleider RS, Friedman MA. Representation of older patients in cancer-treatment trials. Cancer 1994; 74: 2208-2214. | 262 | 9.7 |
| 49. Jackman DM, Yeap BY, Lindeman NI, et al. Phase II clinical trial of chemotherapy-naive patients 70 years of age treated with erlotinib for advanced non-small-cell lung cancer. J Clin Oncol 2007; 25: 760-766. | 258 | 18.43 |
| 50. Perry JR, Laperriere N, O’Callaghan CJ, et al. Short-course radiation plus temozolomide in elderly patients with glioblastoma. N Engl J Med 2017; 376: 1027-1037. | 254 | 63.5 |
| 51. Boyle P. Triple-negative breast cancer in the older population. Ann Oncol 2012; 23: 7-12. | 253 | 28.11 |
| 52. Riley GF, Potosky AL, Lubitz JD, Kessler LG. Medicare payments from diagnosis to death for elderly cancer-patients by stage at diagnosis. Med Care 1995; 33: 828-841. | 249 | 9.58 |
| 53. Begg CB, Carbone PP. Clinical trials and drug toxicity in the elderly. The experience of the Eastern Cooperative Oncology Group. Cancer 1983; 52: 1986-1992. | 247 | 6.5 |
| 54. Schonberg MA, Marcantonio ER, Li DL, Silliman RA, Ngo L, McCarthy EP. Breast cancer among the oldest old: tumor characteristics, treatment choices, and survival. J Clin Oncol 2010; 28: 2038-2045. | 245 | 22.27 |
| 55. Yellen SB, Cella DF, Leslie WT. Age and clinical decision-making in oncology patients. J Natl Cancer Inst 1994; 86: 1766-1770. | 244 | 9.04 |
| 56. Wildiers H, Kunkler I, Biganzoli L, et al. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. Lancet Oncol 2007; 8: 1101-1115. | 243 | 17.36 |
| 57. Soubeyran P, Fonck M, Blanc-Bisson C, et al. Predictors of early death risk in older patients treated with first-line chemotherapy for cancer. J Clin Oncol 2012; 30: 1829-1834. | 241 | 26.78 |
| 58. Powe BD. Fatalism among elderly African-Americans – effects on colorectal cancer screening. Cancer Nurs 1995; 18: 385-392. | 239 | 9.19 |
| 59. Yancik R. Population aging and cancer: a cross-national concern. Cancer J 2005; 11: 437-441. | 238 | 14.88 |
| 60. Janssen-Heijnen MLG, Houterman S, Lemmens V, Louwman MWJ, Maas H, Coebergh JWW. Prognostic impact of increasing age and co-morbidity in cancer patients: a population-based approach. Crit Rev Oncol Hematol 2005; 55: 231-240. | 238 | 14.88 |
| 61. Fong Y, Blumgart LH, Fortner JG, Brennan MF. Pancreatic or liver resection for malignancy is safe and effective for the elderly. Ann Surg 1995; 222: 426-437. | 237 | 9.12 |
| 62. Caillet P, Canoui-Poitrine F, Vouriot J, et al. Comprehensive geriatric assessment in the decision-making process in elderly patients with cancer: ELCAPA Study. J Clin Oncol 2011; 29: 3636-3642. | 234 | 23.4 |
| 63. Colditz GA, Branch LG, Lipnick RJ, et al. Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. Am J Clin Nutr 1985; 41: 32-36. | 234 | 6.5 |
| 64. Yee KWL, Pater JL, Pho L, Zee B, Siu LL. Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier? J Clin Oncol 2003; 21: 1618-1623. | 233 | 12.94 |
| 65. Freyer G, Geay JF, Touzet S, et al. Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO Study. Ann Oncol 2005; 16: 1795-1800. | 231 | 14.44 |
| 66. Jessup JM, Stewart A, Greene FL, Minsky BD. Adjuvant chemotherapy for stage III colon cancer – implications of race/ethnicity, age, and differentiation. JAMA 2005; 294: 2703-2711. | 228 | 14.25 |
| 67. Seymour MT, Thompson LC, Wasan HS, et al. Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial. Lancet 2011; 377: 1749-1759. | 225 | 22.5 |
| 68. Handforth C, Clegg A, Young C, et al. The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol 2015; 26: 1091-1101. | 224 | 37.33 |
| 69. Mery CM, Pappas AN, Bueno R, et al. Similar long-term survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database. Chest 2005; 128: 237-245. | 224 | 14 |
| 70. Mandelblatt JS, Hadley J, Kerner JF, et al. Patterns of breast carcinoma treatment in older women: patient preference and clinical and physician influences. Cancer 2000; 89: 561-573. | 223 | 10.62 |
| 71. Penninx B, Guralnik JM, Pahor M, et al. Chronically depressed mood and cancer risk in older persons. J Natl Cancer Inst 1998; 90: 1888-1893. | 222 | 9.65 |
| 72. Elkin EB, Kim SHM, Casper ES, Kissane DW, Schrag D. Desire for information and involvement in treatment decisions: elderly cancer patients’ preferences and their physicians’ perceptions. J Clin Oncol 2007; 25: 5275-5280. | 220 | 15.71 |
| 73. Wong YN, Mitra N, Hudes G, et al. Survival associated with treatment vs. observation of localized prostate cancer in elderly men (Reprinted from JAMA, vol. 296. 2006). JAMA 2006; 296: 2683-2693. | 220 | 14.67 |
| 74. Hurria A, Mohile S, Gajra A, et al. Validation of a prediction tool for chemotherapy toxicity in older adults with cancer. J Clin Oncol 2016; 34: 2366-2371. | 218 | 43.6 |
| 75. Kristjansson SR, Nesbakken A, Jordhoy MS, et al. Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: a prospective observational cohort study. Crit Rev Oncol Hematol 2010; 76: 208-217. | 218 | 19.82 |
| 76. Davidoff AJ, Tang M, Seal B, Edelman MJ. Chemotherapy and survival benefit in elderly patients with advanced non-small-cell lung cancer. J Clin Oncol 2010; 28: 2191-2197. | 218 | 19.82 |
| 77. Crivellari D, Bonetti M, Castiglione-Gertsch M, et al. Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast cancer: the International Breast Cancer Study Group Trial VII. J Clin Oncol 2000; 18: 1412-1422. | 217 | 10.33 |
| 78. Asmis TR, Ding K, Seymour L, et al. Age and comorbidity as independent prognostic factors in the treatment of non-small-cell lung cancer: a review of national cancer institute of Canada clinical trials group trials. J Clin Oncol 2008; 26: 54-59. | 210 | 16.15 |
| 79. Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 1999; 17: 2412-2418. | 209 | 9.5 |
| 80. Earle CC, Burstein HJ, Winer EP, Weeks JC. Quality of non-breast cancer health maintenance among elderly breast cancer survivors. J Clin Oncol 2003; 21: 1447-1451. | 208 | 11.56 |
| 81. Yancik R, Ganz PA, Varicchio CG, Conley B. Perspectives on comorbidity and cancer in older patients: approaches to expand the knowledge base. J Clin Oncol 2001; 19: 1147-1151. | 206 | 10.3 |
| 82. Rudenstam CM, Zahrieh D, Forbes JF, et al. Randomized trial comparing axillary clearance versus no axillary clearance in older patients with breast cancer: first results of International Breast Cancer Study Group Trial 10-93. J Clin Oncol 2006; 24: 337-344. | 204 | 13.6 |
| 83. Hertog MGL, Feskens EJM, Hollman PCH, Katan MB, Kromhout D. Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Nutr Cancer 1994; 22: 175-184. | 204 | 7.56 |
| 84. Mor V, Allen S, Malin M. The psychosocial impact of cancer on older versus younger patients and their families. Cancer 1994; 74: 2118-2127. | 201 | 7.44 |
| 85. Bouchardy C, Rapiti E, Blagojevic S, Vlastos AT, Vlastos G. Older female cancer patients: Importance, causes, and consequences of undertreatment. J Clin Oncol 2007; 25: 1858-1869. | 199 | 14.21 |
| 86. Mohile SG, Dale W, Somerfield MR, et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology. J Clin Oncol 2018; 36: 2326-2347. | 198 | 66 |
| 87. Newcomb PA, Carbone PP. Cancer treatment and age: patient perspectives. J Natl Cancer Inst 1993; 85: 1580-1584. | 197 | 7.04 |
| 88. Finlayson E, Fan ZH, Birkmeyer JD. Outcomes in octogenarians undergoing high-risk cancer operation: a national study. J Am Coll Surg 2007; 205: 729-734. | 196 | 14 |
| 89. Muss HB, Berry DA, Cirrincione C, et al. Toxicity of older and younger patients treated with adjuvant chemotherapy for node-positive breast cancer: the Cancer and Leukemia Group B experience. J Clin Oncol 2007; 25: 3699-3704. | 195 | 13.93 |
| 90. Extermann M. Measurement and impact of comorbidity in older cancer patients. Crit Rev Oncol Hematol 2000; 35: 181-200. | 195 | 9.29 |
| 91. Tournigand C, Andre T, Bonnetain F, et al. Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer Trial. J Clin Oncol 2012; 30: 3353-3360. | 193 | 21.44 |
| 92. Fulop T, Larbi A, Kotb R, de Angelis F, Pawelec G. Aging, immunity, and cancer. Discov Med 2011; 11: 537-550. | 190 | 19 |
| 93. Hurria A, Cirrincione CT, Muss HB, et al. Implementing a geriatric assessment in cooperative group clinical cancer trials: CALGB 360401. J Clin Oncol 2011; 29: 1290-1296. | 190 | 19 |
| 94. Hakim FT, Flomerfelt FA, Boyiadzis M, Gress RE. Aging, immunity and cancer. Curr Opin Immunol 2004; 16: 151-156. | 190 | 11.18 |
| 95. Puts MTE, Hardt J, Monette J, Girre V, Springall E, Alibhai SMH. Use of geriatric assessment for older adults in the oncology setting: a systematic review. J Natl Cancer Inst 2012; 104: 1133-1163. | 188 | 20.89 |
| 96. Balducci L, Yates J. General guidelines for the management of older patients with cancer. Oncology (Williston Park) 2000; 14: 221-227. | 188 | 8.95 |
| 97. Asahina Y, Tsuchiya K, Tamaki N, et al. Effect of aging on risk for hepatocellular carcinoma in chronic hepatitis C virus infection. Hepatol 2010; 52: 518-527. | 186 | 16.91 |
| 98. Earle CC, Tsai JS, Gelber RD, Weinstein MC, Neumann PJ, Weeks JC. Effectiveness of chemotherapy for advanced lung cancer in the elderly: Instrumental variable and propensity analysis. J Clin Oncol 2001; 19: 1064-1070. | 185 | 9.25 |
| 99. Shibata A, Mack TM, Paganinihill A, Ross RK, Henderson BE. A prospective study of pancreatic cancer in the elderly. Int J Cancer 1994; 58: 46-49. | 184 | 6.81 |
| 100. Pallis AG, Fortpied C, Wedding U, et al. EORTC elderly task force position paper: approach to the older cancer patient. Eur J Cancer 2010; 46: 1502-1513. | 181 | 16.45 |
ACI – adjusted citation index