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. Author manuscript; available in PMC: 2022 Jan 19.
Published in final edited form as: Biochemistry. 2021 Jul 15;60(46):3497–3506. doi: 10.1021/acs.biochem.1c00370

Figure 5:

Figure 5:

Reaction Coordinate for FeII-pterin TPH. A. Effect of pterin binding to FeII on reaction energetics (red to green). B. Schematics of electronic structure contributions of pterin carbonyl coordination on the energetics in A. Red arrow indicates e-donation from FeII to O2, blue arrow indicates e- donation from pterin to O2; the green arrow indicates donation of a second e- from pterin to Fe (to compensate for the Fe donation to the O2). The green electron donation is facilitated by pterin coordination to the Fe (depicted on the right). Adapted from [Iyer, S. R. et al. (2021) Direct coordination of pterin to FeII enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases. Proceedings of the National Academy of Sciences 118.] Copyright [2021].