Figure 6.

Several variants of concern show enhanced entry into ferret ACE2 expressing cells

Mutant SARS-CoV-2 spike-containing pseudovirus entry into HEK 293Ts expressing human or ferret ACE2, or empty vector. Entry normalized to signals from human ACE2 expressing cells. Each data point indicates data from a completely independent repeat (n ≥ 3). Data plotted as mean ± s.d. Statistics were determined by comparing log-transformed values of ferret ACE2 entry using a one-way ANOVA with multiple comparisons against the WT. ^∗0.05 ≥ p > 0.01; ^∗∗0.01 ≥ p > 0.001; ^∗∗∗0.001 ≥ p > 0.0001; ^∗∗∗∗p ≤ 0.0001. RBD mutational profile of the different spike proteins is shown below. Cells in orange indicate changes from WT/D614G. Alpha also known as B.1.1.7; Beta also known as B.1.351; Gamma also known as P.1; Eta also known as B.1.525; Iota also known as B.1.526 + E484K.