Comparison 10. Subligual/buccal vs oral misoprostol: all women.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Vaginal delivery not achieved within 24 hours	2	349	Risk Ratio (M‐H, Fixed, 95% CI)	0.87 [0.68, 1.11]
1.1 Same dose	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.34, 1.16]
1.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.73, 1.22]
2 Uterine hyperstimulation with fetal heart rate changes	2	349	Risk Ratio (M‐H, Fixed, 95% CI)	1.39 [0.28, 6.96]
2.1 Same dose	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 71.92]
2.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.14, 6.93]
3 Caesarean section	2	349	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.57, 1.19]
3.1 Same dose	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	0.53 [0.25, 1.14]
3.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.63, 1.47]
6 Cervix unfavourable/unchanged after 12‐24 hours	2	349	Risk Ratio (M‐H, Fixed, 95% CI)	0.20 [0.03, 1.14]
6.1 Same dose	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	0.09 [0.01, 1.60]
6.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.50 [0.05, 5.40]
7 Oxytocin augmentation	2	349	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.68, 1.07]
7.1 Same dose	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	0.74 [0.45, 1.21]
7.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.70, 1.16]
8 Uterine hyperstimulation without fetal heart rate changes	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	2.48 [0.49, 12.54]
8.1 Same dose	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
8.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	2.48 [0.49, 12.54]
10 Epidural analgesia	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.66, 1.29]
10.1 Same dose	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.66, 1.29]
11 Instrumental vaginal delivery	2	349	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.87, 1.88]
11.1 Same dose	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	1.57 [0.66, 3.72]
11.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [0.78, 1.86]
13 Apgar score < 7 at 5 minutes	2	349	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.06, 15.68]
13.1 Same dose	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
13.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.06, 15.68]
14 Neonatal intensive care unit admission	2	349	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.44, 1.47]
14.1 Same dose	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.27, 2.55]
14.2 Bigger dose orally	1	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.39, 1.63]