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. 2004 Jul 19;2004(3):CD004217. doi: 10.1002/14651858.CD004217.pub2

6. Trials assessing biochemical outcome variables.

Study ID measurement method data reported data preparation
Masciello 1990 blood drawn via heel stick 30 minutes post‐circumcision mean/SD plasma cortisol levels in mg/dL mg/dL multiplied by 27.59 = nmol/L 
 nmol/L included in meta‐analysis
Stang 1988 blood drawn via heel stick for 1/2 subjects at 30 min post‐circumcision, and 90 min for remaining 1/2 subjects mean/SEM plasma cortisol levels in nmol/L and ug/dL means (nmol/L) included in meta‐analysis 
 SEM converted to SD using formula: 
 SD = SEM (sqrt(n))
Williamson 1986 blood drawn by heel stick at baseline and 30 min post‐circumcision mean/SEM plasma cortisol levels in ug/dL SEM converted to SD using formula: 
 SD = SEM (sqrt(n)) 
 ug/dL
Holliday 1999 serum B‐endorphin levels ‐ blood sample taken before and 20 min post‐circumcision mean/SD / group in pmol/L data included as reported
Joyce 2001 salivary cortisol samples collected at baseline abd 30 min after procedure mean/SD before/after 
 no units of measurement 
 results not broken down by group not included
Kurtis 1999 salivary cortisol collected sample at baseline and 30 min post‐circumcision mean/SD included as reported
Stang 1997 plasma cortisol 30 min after beginning of circumcision mean/SD / group 
 nmol/dL and ug/dL mean /SD (nmol/dL) included as reported
Weatherstone 1993 serum B‐endorphin level taken pre‐operatively and 15 min after circumcision mean/SD B‐endorphin level (pg/mL) for pre and post circumcision period/group mean/SD level for post‐circumcision period included as reported
Williamson 1986 plasma cortisol obtained at baseline and 30 min after Gomco clamp applied mean/SEM plasma cortisol levels (ug/dL)/group ug/dL multiplied by 27.59 = nmol/L 
 SEM converted to SD using formula: 
 SD = SEM (sqrt(n))