TABLE 4.
Variable | E. anophelis strains of dominant lineage (n = 226) | Other E. anophelis strains (n = 62) | P value |
---|---|---|---|
Age | 73.4 | 71.9 | 0.456 |
Sex, male, n (%) | 135 (59.7) | 40 (64.5) | 0.495 |
Duration of admission, median (IQR), days | 56 (35.0–84.0) | 44 (28.3–106.7) | 0.057 |
Ward, n (%) | 0.035 | ||
ICU | 79 (35.0) | 29 (46.8) | |
RCC | 53 (23.5) | 6 (9.7) | |
RCW | 46 (20.4) | 11 (17.7) | |
Ward | 48 (21.2) | 15 (24.2) | |
OPD | 0 (0) | 1 (1.6) | |
Period of admission, n (%) | |||
2005−2010 | 0 (0) | 31 (50.0) | < 0.001 |
2011−2015 | 38 (16.8) | 19 (30.6) | |
2016−2020 | 188 (83.2) | 12 (19.4) | |
Charlson comorbidity index, median (IQR) | 3 (2.0–4.0) | 3 (2.0–6.0) | 0.0939 |
Comorbidities, n (%)b | |||
Solid-organ tumor | 35 (15.9) | 15 (24.2) | 0.132 |
Diabetes mellitus | 91 (40.3) | 28 (45.2) | 0.489 |
Chronic pulmonary disease | 41 (18.1) | 12 (19.4) | 0.827 |
Chronic kidney disease | 73 (32.3) | 18 (29.0) | 0.624 |
Hematologic malignancy | 8 (3.5) | 6 (9.7) | 0.047 |
Dementia | 24 (10.6) | 12 (19.4) | 0.066 |
Connective tissue disease | 8 (3.5) | 1 (1.6) | 0.441 |
Chronic liver disease | 32 (14.2) | 13 (21.0) | 0.192 |
Steroid use | 17 (7.5) | 4 (6.5) | 0.774 |
Mechanical ventilation | 177 (78.3) | 29 (46.8) | <0.001 |
Antimicrobial treatment, n (%)b | |||
No treatment | 27 (11.9) | 3 (4.8) | 0.105 |
Aminoglycoside | 3 (1.3) | 2 (3.2) | 0.312 |
Carbapenem | 12 (5.3) | 4 (6.5) | 0.729 |
Cephalosporin | 13 (5.8) | 7 (11.3) | 0.129 |
Glycopeptide | 34 (15.0) | 16 (25.8) | 0.048 |
Fluoroquinolone | 24 (10.6) | 20 (32.3) | <0.001 |
Minocycline | 37 (16.4) | 1 (1.6) | 0.002 |
Penicillinc | 20 (8.8) | 13 (21.0) | 0.008 |
Trimethoprim/sulfamethoxazole | 149 (65.9) | 43 (69.4) | 0.613 |
Mortality, n (%) | |||
14-day mortality | 75 (33.2) | 10 (16.1) | 0.009 |
In hospital mortality | 115 (50.9) | 20 (32.2) | 0.014 |
ICU, intensive care unit; RCC, respiratory care center; RCW, respiratory care ward; OPD, outpatient department.
May be multiple.
Includes ampicillin/sulbactam, piperacillin, piperacillin-tazobactam.