TABLE 1.
rpoB codon exchanges in DNA samples from RIF-resistant clinical isolates without cluster I mutations described in recent studies
| Reference | Isolatea | MICc (μg/ml) | Mutation | Origin | Total no. of Rifr strains analyzed |
|---|---|---|---|---|---|
| 7 | 1Mya105 | >40 | Asia | 90 | |
| 2Ye16 | >40 | ||||
| 3Indn2 | >40 | ||||
| 21 | 69 | 1 | Japan | 95 | |
| 71 | 2 | ||||
| 72 | 4 | ||||
| 75 | 8 | V176F | |||
| 83 | 32 | V176F | |||
| 84 | 32 | V176F | |||
| 3 | 8872 | >2/>1 | V176F | Rwanda | 177 |
| 3662–84 | >2/>1 | New York | |||
| 3518–84 | >2/>1 | ||||
| 1875–65 | >2/>1 | Colorado | |||
| 2 | F364/90 | >2 (256)b | V176F | Mozambique | 41 |
| 362/91 | >2 (64)b | I497F (cluster II) | |||
| 10 | 3200 | >2 | Durban, South Africa | 113 | |
| 1630 | >8 | ||||
| 22 | R17 | >256 | Australia | 33 |
a
Strain designations are those in the original publications.
b
Available for MIC determination in this study.
c
RIF MICs determined or resistance breakpoint concentrations used in the respective study.