Fig. 4. (A–D) TEM (A) and cryo-TEM (B) characterization of Au nanorods assembled on α-synuclein fibrils. Extinction (C) and CD (D) spectra of Au nanorods after 30 min incubation with a control brain homogenate (black curves) and Parkinson's disease-affected brain (red curves). (A–D) Reproduced from ref. 107 with permission from National Academy of Sciences, copyright 2018. (E–J) TEM characterization of (E and F) Au nanorods assembled with hIAPP nanohelices. Reconstructed helical structures from TEM under various tilting angles (F) and from cryo-TEM tomography (G). Scheme of the cross-polarization optical setup and the differences in transmitted light between pure Au NPs (almost no transmission) and NR-hIAPP assemblies (intense red transmitted light) (H). Photographs of transmitted red light for AU-hIAPP assemblies with different g-factors and IAPP concentrations (I). Inhibition effect of increasing epigallocatechin gallate (EGCG) and D-NFGAIL peptide concentration translated into the loss of transmitted intensity (J). (E–J) Reproduced from ref. 34 with permission from The American Association for the Advancement of Science, copyright 2021.