TABLE 3.
Temporal trends in 24‐hours and 90‐days outcomes of acute ischemic stroke in patients treated with intravenous or intraarterial tPA
| All | October 2010–September 2011 | October 2011–September 2012 | October 2012–September 2013 | October 2013–September 2014 | October 2014–September 2015 | October 2015–September 2016 | October 2016–September 2017 | October 2017–September 2018 | P‐trend | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N = 4224 | Missing values | n = 369 | n = 401 | n = 463 | n = 466 | n = 502 | n = 595 | n = 638 | n = 790 | ||
| Any ICH (%) | |||||||||||
| ‐ HI type 1 (%) | 252 (5.97%) | 63 (1.49%) | 24 (6.50%) | 21 (5.24%) | 25 (5.40%) | 23 (4.94%) | 28 (5.58%) | 32 (5.38%) | 45 (7.05%) | 54 (6.84%) | 0.2343 |
| ‐ HI type 2 (%) | 185 (4.38%) | 63 (1.49%) | 19 (5.15%) | 15 (3.74%) | 18 (3.89%) | 14 (3.00%) | 18 (3.59%) | 28 (4.71%) | 33 (5.17%) | 40 (5.06%) | 0.2423 |
| ‐ PH type 1 (%) | 122 (2.89%) | 63 (1.49%) | 11 (2.98%) | 14 (3.49%) | 15 (3.24%) | 10 (2.15%) | 10 (1.99%) | 19 (3.19%) | 22 (3.45%) | 21 (2.66%) | 0.8436 |
| ‐ PH type 2 (%) | 138 (3.27%) | 63 (1.49%) | 15 (4.07%) | 11 (2.74%) | 16 (3.46%) | 24 (5.15%) | 15 (2.99%) | 13 (2.18%) | 18 (2.82%) | 26 (3.29%) | 0.2969 |
| Symptomatic ICH (%) | 139 (3.29%) | 102 (2.41%) | 13 (3.52%) | 12 (2.99%) | 8 (1.73%) | 14 (3.00%) | 21 (4.18%) | 22 (3.70%) | 25 (3.92%) | 24 (3.04%) | 0.4414 |
| Systemic hemorrhage (%) | 144 (3.41%) | 82 (1.94%) | 6 (1.63%) | 20 (4.99%) | 11 (2.38%) | 16 (3.43%) | 24 (4.78%) | 15 (2.52%) | 22 (3.45%) | 30 (3.80%) | 0.4316 |
| 24 hours‐NIHSS (median [IQR]) | 5 [1;12] | 974 (23.06%) | 6 [2;14] | 6 [2;14] | 5 [2;13] | 5 [1;12] | 4 [1;11.75] | 5 [1;12] | 4 [1;11] | 3 [1;11] | < 0.0001X |
| 24 hours‐NIHSS < 5 | 1620 (38.35%) | 974 (23.06%) | 153 (41.46%) | 148 (36.91%) | 191 (41.25%) | 190 (40.77%) | 212 (42.23%) | 236 (39.66%) | 242 (37.93%) | 248 (31.39%) | 0.0015 |
| mRS at 3 months (median [IQR]) | 2 [0;4] | 1020 (24.15%) | 2 [1;4] | 2 [1;4] | 2 [0;4] | 2 [0;4] | 2 [0;4] | 1 [0;4] | 2 [0;4] | 2 [0;4] | 0.22931X |
| mRS ≤ 1 (%) | 1461 (34.59%) | 1020 (24.15%) | 137 (37.13%) | 119 (29.68%) | 155 (33.48%) | 147 (31.55%) | 176 (35.06%) | 235 (39.50%) | 225 (35.27%) | 267 (33.80%) | 0.3563 |
| mRS ≤ 2 (%) | 1874 (44.37%) | 1020 (24.15%) | 178 (48.24%) | 167 (41.65%) | 193 (41.68%) | 202 (43.35%) | 220 (43.82%) | 293 (49.24%) | 277 (43.42%) | 344 (43.54%) | 0.9721 |
| All‐cause mortality at 3 months (%) | 559 (13.23%) | 1780 (42.14%) | 54 (14.63%) | 42 (10.47%) | 59 (12.74%) | 67 (14.38%) | 57 (11.35%) | 76 (12.77%) | 84 (13.17%) | 120 (15.19%) | 0.2791 |
Note: Temporal linear trends were assessed using the Pearson Χ 2 for categorical variables and Mann‐Kendall trend test for continuous variables.
Abbreviations: HI, hemorrhagic infarction; ICH, intracerebral hemorrhage; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; PH, parenchymal hematoma.