Table 2.

Different biomarker express in different location.

Location	ALK+	EGFR+	RET+	T790M	TTF-1	CK7	RB1 protein	TMB	PD-L1	Ki-67	microRNA135b
UL		Higher [71]						Higher [74]	Higher [74]
LL	+[38]	Lower [70]
ML								Higher [74]	Higher [74]
Peripheral		+[123] Higher [8]	+[72]	+[40]	+[8]	+[8]	+[123]	Higher [76]		+[42]	+[77]
Central	+[36, 37]								+[124]

+: Expression; ALK: Anaplastic lymphoma kinase; EGFR: Epidermal growth factor receptor; LL: Lower lobe; LUL: Left upper lobe; LLL: Left lower lobe; ML: Middle lobe; PD-L1: Programmed death-ligand1; RLL: Right lower lobe; RUL: Right upper lobe; TTF-1: Thyroid transcription factor-1; TMB: Tumor mutational burden; UL: Upper lobe.