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. 2022 Jan 19;16(1):e0010039. doi: 10.1371/journal.pntd.0010039

Table 3. Comparison of the incidence of nonvariceal upper GI bleeding (stratified by age).

Age Days after infection Dengue cohort Nondengue cohort Crude HR (95% CI) P-value Adjusted HR* (95% CI) P-value Adjusted SHR† (95% CI) P-value
No. of events Incidence rate (per 1000 person-months) No. of events Incidence rate (per 1000 person-months)
≤ 50 ≤ 30 67 8.82 3 0.10 89.64 (28.20–284.92) < 0.0001 85.42 (26.83–271.93) < 0.0001 85.41 (26.96–270.61) < 0.0001
> 30 41 0.05 178 0.06 0.92 (0.66–1.29) 0.630 0.85 (0.61–1.20) 0.360 0.87 (0.61–1.22) 0.409
31–365 5 0.06 8 0.02 2.50 (0.82–7.65) 0.108 2.05 (0.66–6.43) 0.217 2.05 (0.68–6.12) 0.200
> 365 36 0.05 170 0.06 0.85 (0.59–1.21) 0.360 0.77 (0.54–1.11) 0.168 0.79 (0.55–1.14) 0.199
51–64 ≤ 30 72 20.62 4 0.28 72.72 (26.57–199.03) < 0.0001 73.68 (26.86–202.06) < 0.0001 73.59 (26.83–201.84) < 0.0001
> 30 92 0.25 332 0.23 1.11 (0.88–1.40) 0.386 1.02 (0.81–1.29) 0.865 1.04 (0.82–1.32) 0.725
31–365 8 0.20 36 0.23 0.89 (0.42–1.92) 0.772 0.86 (0.40–1.87) 0.707 0.87 (0.40–1.88) 0.716
> 365 84 0.26 296 0.23 1.13 (0.89–1.44) 0.313 1.04 (0.81–1.32) 0.772 1.06 (0.83–1.36) 0.657
≥ 65 ≤ 30 56 31.27 7 0.94 32.53 (14.83–71.36) < 0.0001 31.78 (14.43–70.01) < 0.0001 31.72 (14.29–70.41) < 0.0001
> 30 114 0.71 429 0.67 1.06 (0.86–1.30) 0.596 0.98 (0.80–1.21) 0.881 1.02 (0.83–1.26) 0.829
31–365 10 0.50 66 0.81 0.61 (0.32–1.19) 0.148 0.60 (0.31–1.17) 0.134 0.60 (0.31–1.19) 0.144
> 365 104 0.73 363 0.64 1.14 (0.91–1.41) 0.248 1.05 (0.85–1.31) 0.646 1.09 (0.87–1.35) 0.454

Adjusted HR*: Hazard ratio adjusted for age, sex, area of residence, comorbidities, and medications listed in Table 1.

Adjusted SHR† Subdistribution hazard ratio adjusted for age, sex, area of residence, comorbidities, and medications listed in Table 1.