Table 3. List of predicted proteases with calculated activity score.
| Activity Score (Peptide database) | Nakagawa CKD Kidney (Discovery Set) | Nakagawa CKD Kidney (Validation Set) | Ju CKD Glom | Ju CKD TubInt | Protein expression | |
| Proteases | CKD cohort | CKD cohort | CKD cohort | CKD cohort | CKD cohort | |
| MMP9 | -18.47 | Increase | Not significant* | Not significant* | Not significant* | inconclusive* |
| MMP13 | -22.44 | Increase | Increase | Not significant* | Not significant* | - |
| MMP2 | -13.28 | Decrease | Not Significant* | Increase | Increase | inconclusive* |
| MMP14 | -7.59 | Decrease | Decrease | Decrease | Not significant* | - |
| PCSK6 | 7.08 | Decrease | Increase | Decrease | Decrease | - |
| PCSK7 | 7.08 | Decrease | Increase | Increase | Not significant* | - |
| PCSK4 | 7.08 | No data | No data | No data | No data | - |
| PCSK5 | 7.08 | Increase | Increase | Increase | Increase | - |
| MMP3 | -6.33 | Increase | Increase | Increase | Not significant* | - |
| MMP12 | -6.33 | Decrease | Increase | Not significant* | Not significant* | Increase [61] |
| MMP8 | -4.62 | Increase | Increase | Not significant* | Not significant* | - |
| KLK4 | 10.53 | Increase | No data | No data | No data | - |
| MMP20 | -5.06 | Increase | Increase | Not significant* | Not significant* | - |
| MMP1 | -1.72 | Increase | Not Significant* | Increase | Increase | - |
| MMP7 | 5.26 | Increase | Increase | Increase | Increase | Increase [11, 62] |
| MMP26 | 0 | Increase | Not Significant* | Decrease | Not significant* | - |
* Not significant: P > 0.05, inconclusive*: some studies reported increased, some decreased protein expression levels in CKD and some reported no statistically significant difference between CKD and the compared groups. Abbreviations: MMP = Matrix metalloproteinase; PCSK = Proprotein convertase subtilisin/kexin type; KLK4 = Kallikrein-4.