Table 1. List of antidepressants included in the older and newer cohorts of RCTs.

Drug group and cohort of RCTs	Approval date	Generic name	Brand name
Older [2]	December 1987	fluoxetine	Prozac
	December 1992	paroxetine	Paxil
	December 1993	venlafaxine	Effexor
	December 1994	nefazodone	Serzone
	June 1996	mirtazapine	Remeron
	October 1996	bupropion sustained release	Wellbutrin SR
	July 1997	sertraline	Zoloft
	October 1997	venlafaxine extended release	Effexor XR
	July 1998	citalopram	Celexa
	December 1999	paroxetine controlled release	Paxil CR
	August 2002	escitalopram	Lexapro
Newer	February 2008	desvenlafaxine	Pristiq
	January 2011	vilazodone	Viibryd
	July 2013	levomilnacipran	Fetzima
	September 2013	vortioxetine	Trintellix

RCT, randomized controlled trial.