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. 2022 Jan 19;17(1):e0260993. doi: 10.1371/journal.pone.0260993

Table 3. Interactions in associations with myopia (all, childhood-onset and adult-onset) between year of birth and no educational qualifications.

    Educational attainment adjusted Odds Ratios (95% confidence interval)
    No qualification O level A level Higher level
All myopia, n = 28,074
Year of birth
1939–44 1 1.91 (1.73, 2.10) 1.91 (1.65, 2.20) 2.70 (2.51, 2.90)
1945–49 vs 1939–44 0.97 (0.90, 1.05) 0.99 (0.86, 1.15) 1.08 (0.99, 1.18) 1.10 (0.98, 1.23)
vs No qualification 1 1.95 (1.72, 2.21) 2.12 (1.86, 2.41) 3.06 (2.72, 3.43)
1950–54 vs 1939–44 0.92 (0.75, 1.13) 0.94 (0.68, 1.30) 1.02 (0.77, 1.35) 1.04 (0.83, 1.31)
vs No qualification 1 1.87 (1.45, 2.41) 2.20 (1.73, 2.80) 3.47 (2.77, 4.35)
1955–59 vs 1939–44 0.86 (0.69, 1.07) 0.88 (0.65, 1.18) 0.96 (0.76, 1.20) 0.98 (0.84, 1.14)
vs No qualification 1 1.94 (1.61, 2.35) 2.33 (1.95, 2.80) 3.50 (2.81, 4.36)
1960–64 vs 1939–44 0.77 (0.58, 1.03) 0.79 (0.62, 1.19) 0.86 (0.62, 1.19) 0.88 (0.69, 1.11)
vs No qualification 1 1.71 (1.34, 2.17) 2.37 (1.77, 3.17) 3.52 (2.59, 4.78)
1965–70 vs 1939–44 0.58 (0.49, 0.68) 0.59 (0.44, 0.80) 0.64 (0.48, 0.86) 0.65 (0.51, 0.84)
vs No qualification 1 1.96 (1.59, 2.41) 2.69 (2.23, 3.25) 4.17 (3.32, 5.22)
Adult-onset myopia, n = 11,685
Year of birth
1939–44 1 1.81 (1.44, 2.29) 1.77 (1.44, 2.19) 2.05 (1.81, 2.32)
1945–49 vs 1939–44 1.14 (0.98, 1.32) 1.03 (0.87, 1.22) 1.06 (0.96, 1.17) 1.08 (0.96, 1.20)
vs No qualification 1 1.64 (1.47, 1.83) 1.65 (1.51, 1.80) 1.94 (1.76, 2.14)
1950–54 vs 1939–44 1.24 (0.96, 1.62) 1.12 (0.82, 1.55) 1.16 (0.83, 1.62) 1.18 (0.88, 1.57)
vs No qualification 1 1.54 (1.17, 2.03) 1.61 (1.22, 2.12) 2.03 (1.50, 2.75)
1955–59 vs 1939–44 1.22 (1.02, 1.45) 1.10 (0.74, 1.64) 1.13 (0.90, 1.43) 1.15 (0.96, 1.38)
vs No qualification 1 1.77 (1.36, 2.31) 1.86 (1.44, 2.40) 2.19 (1.74, 2.76)
1960–64 vs 1939–44 1.13 (0.83, 1.53) 1.02 (0.69, 1.50) 1.05 (0.79, 1.39) 1.07 (0.87, 1.31)
vs No qualification 1 1.52 (1.15, 2.00) 1.92 (1.39, 2.63) 2.43 (1.71, 3.44)
1965–70 vs 1939–44 0.88 (0.67, 1.14) 0.80 (0.58, 1.10) 0.82 (0.58, 1.15) 0.83 (0.61, 1.13)
vs No qualification 1 1.59 (1.24, 2.04) 2.02 (1.55, 2.65) 2.63 (2.03, 3.41)
Childhood-onset myopia, n = 16,389
Year of birth
1939–44 1 1.99 (1.77, 2.36) 2.06 (1.68, 2.52) 3.33 (2.77, 3.99)
1945–49 vs 1939–44 0.85 (0.72, 1.00) 0.97 90.81, 1.16) 1.09 (0.99, 1.20) 1.12 (0.99, 1.25)
vs No qualification 1 2.27 (1.90, 2.72) 2.66 (2.25, 3.11) 4.37 (3.92, 4.87)
1950–54 vs 1939–44 0.67 (0.53, 0.85) 0.76 (0.50, 1.17) 0.86 (0.61, 1.20) 0.88 (0.67, 1.15)
vs No qualification 1 2.37 (1.91, 2.94) 3.13 (2.49, 3.93) 5.80 (4.59, 7.34)
1955–59 vs 1939–44 0.58 (0.43, 0.78) 0.66 (0.42, 1.06) 0.74 (0.49, 1.14) 0.76 (0.53, 1.09)
vs No qualification 1 2.26 (1.71, 2.99) 3.21 (2.66, 3.88) 5.96 (4.27, 8.30)
1960–64 vs 1939–44 0.49 (0.36, 0.68) 0.56 (0.33, 0.95) 0.63 (0.41, 0.97) 0.65 (0.45, 0.92)
vs No qualification 1 2.07 (1.55, 2.77) 3.32 (2.40, 4.57) 5.83 (4.05, 8.40)
1965–70 vs 1939–44 0.33 (0.26, 0.41) 0.37 (0.26, 0.53) 0.42 (0.31, 0.57) 0.43 (0.34, 0.55)
  vs No qualification 1 2.85 (1.74, 4.69) 4.36 (2.65, 7.22) 8.04 (4.19, 13.1)

*Adjusted by sex vs educational qualification interaction, accommodation tenure, ethnicity, variance adjustment by test centre. Bold fonts indicate significant within cohort associations at the 5% level.