TABLE 2.
Tissue analyzed | Lesion type | Presence of lesion after euthanasia on postinfection daya
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
3 | 5 | 7 | 10 | 12 | 14 | 17 | 19 | 21 | 31 | ||
Oral cavity | Intraepithelial vesicles | X | X | X | |||||||
Erosion with reparation | X | X | X | ||||||||
Perivascular lymphocytic inflammation in submucosa, focal degeneration in the epithelium, inclusions in the cytoplasm of epithelial cells | X | ||||||||||
Esophagus | Vacuolization in the stratum spinosum and stratum splanocellulare | X | |||||||||
Rumen | Localized chronic purulent inflammation- | X | X | ||||||||
Focal epithelial regeneration | X | ||||||||||
Abomasum | Subacute inflammation in the mucosa | X | X | ||||||||
Epithelial regeneration | X | ||||||||||
Small and large intestines | Eosinophil infiltration | X | X | X | X | X | X | X | X | X | X |
Peyer's patches and ileocecal valve | Eosinophil granulocyte infiltration | X | X | X | X | ||||||
Lymphoid depletion | X | X | X | ||||||||
Lymphoid depletion and mitosis | X | X | X | ||||||||
Mesenteric lymph node | Hyperplasia of germinal centers and eosinophil granulocyte infiltration | X | X | X | X | ||||||
Hyperplasia of germinal centers and necrosis | X | ||||||||||
Lymphoid depletion and mitosis | X | X | X | X | X | ||||||
Thymus | Mild lymphoid depletion in the cortex | X | X | X | X | X | X | ||||
Tonsils | Follicular hyperplasia | X | X | X | X | ||||||
Hyperplasia of germinal centers and necrosis | X | X | |||||||||
Lymphoid degeneration, mild lymphoid depletion | X | ||||||||||
Lymphoid depletion and mitosis in the germinal centers | X | X | X | ||||||||
Retropharyngeal and peribronchial lymph node | Hyperplasia of germinal centers | X | X | X | X | X | X | ||||
Hyperplasia of germinal centers and necrosis | X | ||||||||||
Lymphoid depletion and mitosis in the germinal centers | X | X | X | ||||||||
Nasal cavity and trachea | Acute catarrhal inflammation | X | X | X | X | ||||||
Subacute inflammation | X | X | X | X | X | X | |||||
Lung | Peribronchial lymphoid hyperplasia | X | X | X | |||||||
Focal intralobular interstitial pneumonia | X | X | X | X | X | X | X | ||||
Bronchiolitis and focal atelectasis | X | ||||||||||
Hyperplasia of the media of small arteries | X | X | |||||||||
Heart muscle | Subacute focal myocardial necrosis | X | |||||||||
Lymphocytic perivasculitis, lymphocytic myocarditis | X | ||||||||||
Brain | Perivascular lymphohistiocytic inflammation in the brain stem | X | X | ||||||||
Panencephalitis | X | ||||||||||
Spleen | Infiltration with neutrophil granulocytes in the red pulp | X | X | ||||||||
Hyperplasia of Malpighian bodies | X | X | X | ||||||||
Hyperplasia of Malpighian bodies and necrosis in the lymphocytes | X | ||||||||||
Lymphoid depletion in the Malpighian bodies | X | X | |||||||||
Lymphoid depletion in the Malpighian bodies and mitosis | X | X | X | ||||||||
Liver | Focal subacute inflammation | X | X | X | X | ||||||
Kidney | Mild focal interstitial inflammation | X | X | X | X | ||||||
Proliferation of mesangium cells in the glomeruli | X | X |
X, lesion present.