TABLE 2.

Histopathological lesions in tissue specimens of calves infected with cp isolate BVDV Mo1 in experiment 2 and euthanized at different days postinfection

Tissue analyzed	Lesion type	Presence of lesion after euthanasia on postinfection daya
		3	5	7	10	12	14	17	19	21	31
Oral cavity	Intraepithelial vesicles		X	X				X
	Erosion with reparation						X	X	X
	Perivascular lymphocytic inflammation in submucosa, focal degeneration in the epithelium, inclusions in the cytoplasm of epithelial cells						X
Esophagus	Vacuolization in the stratum spinosum and stratum splanocellulare		X
Rumen	Localized chronic purulent inflammation-		X				X
	Focal epithelial regeneration								X
Abomasum	Subacute inflammation in the mucosa							X		X
	Epithelial regeneration								X
Small and large intestines	Eosinophil infiltration	X	X	X	X	X	X	X	X	X	X
Peyer's patches and ileocecal valve	Eosinophil granulocyte infiltration	X	X	X	X
	Lymphoid depletion					X	X	X
	Lymphoid depletion and mitosis								X	X	X
Mesenteric lymph node	Hyperplasia of germinal centers and eosinophil granulocyte infiltration	X	X	X	X
	Hyperplasia of germinal centers and necrosis					X
	Lymphoid depletion and mitosis						X	X	X	X	X
Thymus	Mild lymphoid depletion in the cortex				X	X	X	X	X	X
Tonsils	Follicular hyperplasia	X	X							X	X
	Hyperplasia of germinal centers and necrosis			X	X
	Lymphoid degeneration, mild lymphoid depletion					X
	Lymphoid depletion and mitosis in the germinal centers						X	X	X
Retropharyngeal and peribronchial lymph node	Hyperplasia of germinal centers	X	X	X	X					X	X
	Hyperplasia of germinal centers and necrosis					X
	Lymphoid depletion and mitosis in the germinal centers						X	X	X
Nasal cavity and trachea	Acute catarrhal inflammation	X	X	X	X
	Subacute inflammation					X	X	X	X	X	X
Lung	Peribronchial lymphoid hyperplasia	X	X	X
	Focal intralobular interstitial pneumonia				X	X	X	X	X	X	X
	Bronchiolitis and focal atelectasis								X
	Hyperplasia of the media of small arteries					X			X
Heart muscle	Subacute focal myocardial necrosis						X
	Lymphocytic perivasculitis, lymphocytic myocarditis								X
Brain	Perivascular lymphohistiocytic inflammation in the brain stem		X								X
	Panencephalitis									X
Spleen	Infiltration with neutrophil granulocytes in the red pulp	X	X
	Hyperplasia of Malpighian bodies	X								X	X
	Hyperplasia of Malpighian bodies and necrosis in the lymphocytes			X
	Lymphoid depletion in the Malpighian bodies				X	X
	Lymphoid depletion in the Malpighian bodies and mitosis						X	X	X
Liver	Focal subacute inflammation						X	X	X	X
Kidney	Mild focal interstitial inflammation	X	X	X							X
	Proliferation of mesangium cells in the glomeruli				X					X

^aX, lesion present.