Fig. 3. Photomicrographs (magnification ×40 or ×200) of the current case. HE staining showed proliferation of atypical glial cells and necrosis. Abnormal proliferation of vessels was observed around necrosis (A). Microvascular proliferation was also observed, which strongly suggested glioblastoma pathology (B). Immunohistochemical staining of IDH1R132H yielded negative results (C). The absence of IDH1 and IDH2 mutations was also confirmed by Sanger sequencing. HE: hematoxylin–eosin, IDH: isocitrate dehydrogenase.
