Table 2.
Relationship between DNAm estimated plasma proteins and Parkinson’s disease
| Model 1: Age, Sex, Ancestry, Smoking | Model 2: Age, Sex, Ancestry, Smoking, Cell Comp | |||
|---|---|---|---|---|
| Predictor: | OR | 95%CI | OR | 95%CI |
| DNAm CD56 | 1.41 | 1.11, 1.79* | 1.34 | 1.05, 1.70* |
| DNAm EFEMP-1 | 0.83 | 0.70, 0.98* | 0.80 | 0.68, 0.95* |
| DNAm B2M | 1.20 | 1.02, 1.41* | 1.14 | 0.97, 1.34 |
| DNAm TIMP-1 | 1.23 | 1.03, 1.46* | 1.06 | 0.88, 1.29 |
| DNAm Cystatin-C | 1.19 | 1.00, 1.42* | 1.11 | 0.93, 1.32 |
| DNAm ADM | 1.21 | 0.99, 1.47 | 1.13 | 0.92, 1.38 |
| DNAm PON1 | 0.90 | 0.77, 1.05 | 0.91 | 0.77, 1.07 |
| DNAm Leptin | 0.84 | 0.62, 1.13 | 0.89 | 0.65, 1.20 |
| DNAm PAI-1 | 0.93 | 0.80, 1.09 | 0.93 | 0.79, 1.09 |
| DNAm GDF-15 | 1.07 | 0.90, 1.26 | 1.04 | 0.88, 1.23 |
| DNAm Ceruloplasmin | 1.16 | 0.68, 1.99 | 1.31 | 0.76, 2.27 |
| DNAm Myoglobin | 1.07 | 0.83, 1.38 | 1.04 | 0.81, 1.33 |
* =
significant associations (p < 0.05)
Each DNAm marker is modeled in a univariate logistic regression with all covariates and the DNAm marker included in the same model. Odds Ratio per 1 SD of DNAm plasma protein levels.