Table 1.
Adverse effects experienced by 6 patients with refractory chronic migraine who underwent 5-day continuous ketamine infusion.
| Patient | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | |
|---|---|---|---|---|---|---|
| A: 20 yo female, 64 kg | Maximum ketamine rate (mg/h) | 30 (0.5 mg/kg/h) | 60 (0.9 mg/kg/h) | 68 (1 mg/kg/h) | 60 (0.9 mg/kg/h) | 64 (1 mg/kg/h) |
| Adverse Effects | None | Nausea/vomiting | Blurry vision; nausea/vomiting | Blurry vision; hallucinations; nausea/vomiting | Blurry vision; nausea/vomiting | |
| B: 54 yo male, 84 kg | Maximum ketamine rate (mg/h) | 30 (0.4 mg/kg/h) | 60 (0.7 mg/kg/h) | 60 (0.7 mg/kg/h) | 85 (1 mg/kg/h) | 60 (0.7 mg/kg/h) |
| Adverse Effects | None | Blurry vision; hallucinations | Blurry vision; hallucinations | Blurry vision | Blurry vision | |
| C: 48 yo female, 83 kg | Maximum ketamine rate (mg/h) | 30 (0.4 mg/kg/h) | 60 (0.7 mg/kg/h) | 65 (0.8 mg/kg/h) | 70 (0.8 mg/kg/h) | 75 (0.9 mg/kg/h) |
| Adverse Effects | None | Blurry vision; nausea/vomiting | Blurry vision; nausea/vomiting | Blurry vision | Blurry vision; nausea/vomiting | |
| D: 28 yo male, 82 kg | Maximum ketamine rate (mg/h) | 30 (0.4 mg/kg/h) | 40 (0.5 mg/kg/h) | 50 (0.6 mg/kg/h) | 55 (0.7 mg/kg/h) | 50 (0.6 mg/kg/h) |
| Adverse Effects | None | Blurry vision; vivid dreams | Blurry vision; vivid dreams | Blurry vision; hallucinations; nightmares | Blurry vision | |
| E: 55 yo female, 69 kg | Maximum ketamine rate (mg/h) | 10 (0.1 mg/kg/h) | 40 (0.6 mg/kg/h) | 60 (0.9 mg/kg/h) | 72 (1 mg/kg/h) | 65 (0.9 mg/kg/h) |
| Adverse Effects | None | Nausea/vomiting | None | None | Blurry vision; nausea/vomiting | |
| F: 36 yo male, 94 kg | Maximum ketamine rate (mg/h) | 30 (0.3 mg/kg/h) | 50 (0.5 mg/kg/h) | 70 (0.7 mg/mg/h) | 80 (0.9 mg/kg/h) | 80 (0.9 mg/kg/h) |
| Adverse Effects | None | Blurry vision; nausea/vomiting | Blurry vision; nausea/vomiting | Blurry vision; nausea/vomiting | Nausea/vomiting |