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EX 527 blunted cellular sirtuin 1 (Sirt1) and AMP activated protein kinase (AMPK) signaling whereas compound C reduced p-AMPK expression without affecting Sirt1 signaling. (A) Representative images of Western blotting; (B) Sirt1, AMPK, and p-AMPK expression; (C) p-AMPK/AMPK ratio. Data are presented as the mean±SEM, n=3 per group. **P<0.01 vs NG; ##P<0.01 vs HG; &&P<0.01 vs HG+LRG
NG: normal glucose; HG: high glucose; LRG: liraglutide
